EIF1AY report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EIF1AY at tissue level.

III. Associated gene sets

GO_0006413Biological processtranslational initiation
GO_0005737Cellular componentcytoplasm
GO_0003743Molecular functiontranslation initiation factor activity
GO_0000049Molecular functiontRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEIF1AY
Protein nameEukaryotic translation initiation factor 4C
Eukaryotic translation initiation factor 1A Y-linked
Alternative protein EIF1AY
Eukaryotic translation initiation factor 1A, Y-chromosomal (eIF-1A Y isoform) (eIF1A Y isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C)
Synonyms
DescriptionFUNCTION: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. .

FUNCTION: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. .

AccessionsENST00000361365.7
L8EAB4
A0A1I9KF45
A6NJH9
A0A1I9KGH8
O14602
ENST00000382772.3