Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 12 studies | 26% ± 7% | |
naive B cell | 11 studies | 22% ± 6% | |
memory B cell | 8 studies | 21% ± 3% | |
plasmacytoid dendritic cell | 7 studies | 23% ± 6% | |
CD4-positive, alpha-beta T cell | 5 studies | 20% ± 2% | |
erythrocyte | 5 studies | 27% ± 13% | |
basal cell | 4 studies | 25% ± 12% | |
CD8-positive, alpha-beta T cell | 4 studies | 19% ± 1% | |
regulatory T cell | 4 studies | 18% ± 3% | |
non-classical monocyte | 3 studies | 19% ± 2% | |
plasma cell | 3 studies | 22% ± 7% | |
epithelial cell | 3 studies | 21% ± 5% |
Insufficient scRNA-seq data for expression of EIF1AY at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 1311.02 | 245 / 245 | 99% | 23.98 | 497 / 502 |
brain | 72% | 689.31 | 1907 / 2642 | 56% | 11.36 | 394 / 705 |
liver | 71% | 673.74 | 161 / 226 | 54% | 8.27 | 219 / 406 |
bladder | 67% | 1013.57 | 14 / 21 | 54% | 10.88 | 272 / 504 |
kidney | 78% | 1145.67 | 69 / 89 | 43% | 6.24 | 387 / 901 |
pancreas | 63% | 446.54 | 207 / 328 | 52% | 7.40 | 93 / 178 |
lung | 68% | 834.71 | 393 / 578 | 47% | 7.66 | 547 / 1155 |
skin | 67% | 676.11 | 1203 / 1809 | 47% | 9.39 | 223 / 472 |
esophagus | 66% | 904.01 | 952 / 1445 | 46% | 6.05 | 85 / 183 |
intestine | 64% | 978.79 | 619 / 966 | 44% | 8.50 | 232 / 527 |
stomach | 64% | 709.32 | 228 / 359 | 41% | 6.05 | 116 / 286 |
ureter | 0% | 0 | 0 / 0 | 100% | 23.18 | 1 / 1 |
thymus | 66% | 722.14 | 434 / 653 | 30% | 7.45 | 180 / 605 |
adrenal gland | 61% | 1073.06 | 157 / 258 | 35% | 8.72 | 80 / 230 |
heart | 68% | 3227.87 | 585 / 861 | 0% | 0 | 0 / 0 |
adipose | 68% | 886.20 | 816 / 1204 | 0% | 0 | 0 / 0 |
muscle | 68% | 2255.12 | 543 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 67% | 17.05 | 30 / 45 |
blood vessel | 66% | 1081.30 | 879 / 1335 | 0% | 0 | 0 / 0 |
breast | 63% | 804.50 | 291 / 459 | 1% | 0.27 | 10 / 1118 |
spleen | 64% | 1752.52 | 154 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 64% | 1117.36 | 591 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 45% | 15.45 | 13 / 29 |
eye | 0% | 0 | 0 / 0 | 28% | 4.47 | 22 / 80 |
uterus | 0% | 0 | 0 / 170 | 7% | 1.40 | 31 / 459 |
ovary | 1% | 1.36 | 1 / 180 | 0% | 0 | 0 / 430 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006413 | Biological process | translational initiation |
GO_0005737 | Cellular component | cytoplasm |
GO_0003743 | Molecular function | translation initiation factor activity |
GO_0000049 | Molecular function | tRNA binding |
GO_0005515 | Molecular function | protein binding |
Gene name | EIF1AY |
Protein name | Eukaryotic translation initiation factor 4C Eukaryotic translation initiation factor 1A Y-linked Alternative protein EIF1AY Eukaryotic translation initiation factor 1A, Y-chromosomal (eIF-1A Y isoform) (eIF1A Y isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C) |
Synonyms | |
Description | FUNCTION: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. . FUNCTION: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. . |
Accessions | ENST00000361365.7 L8EAB4 A0A1I9KF45 A6NJH9 A0A1I9KGH8 O14602 ENST00000382772.3 |