Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 9 studies | 25% ± 8% | |
astrocyte | 7 studies | 31% ± 13% | |
macrophage | 7 studies | 25% ± 10% | |
classical monocyte | 6 studies | 19% ± 4% | |
goblet cell | 6 studies | 33% ± 18% | |
microglial cell | 6 studies | 25% ± 8% | |
epithelial cell | 6 studies | 28% ± 6% | |
fibroblast | 6 studies | 18% ± 4% | |
oligodendrocyte | 6 studies | 28% ± 7% | |
plasma cell | 5 studies | 26% ± 7% | |
endothelial cell of lymphatic vessel | 5 studies | 22% ± 4% | |
glutamatergic neuron | 5 studies | 46% ± 25% | |
adipocyte | 4 studies | 18% ± 3% | |
ciliated cell | 4 studies | 21% ± 4% | |
GABAergic neuron | 4 studies | 48% ± 17% | |
oligodendrocyte precursor cell | 4 studies | 31% ± 9% | |
interneuron | 4 studies | 42% ± 24% | |
neuron | 3 studies | 25% ± 13% | |
dendritic cell | 3 studies | 18% ± 1% | |
plasmacytoid dendritic cell | 3 studies | 18% ± 2% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 6 studies | 40% ± 18% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2403.99 | 1445 / 1445 | 100% | 45.59 | 183 / 183 |
lung | 100% | 3564.88 | 578 / 578 | 100% | 31.93 | 1153 / 1155 |
breast | 100% | 2952.85 | 459 / 459 | 99% | 50.55 | 1112 / 1118 |
pancreas | 100% | 4062.23 | 328 / 328 | 99% | 33.87 | 177 / 178 |
prostate | 100% | 2563.26 | 244 / 245 | 99% | 47.12 | 499 / 502 |
brain | 99% | 1826.96 | 2616 / 2642 | 99% | 24.06 | 701 / 705 |
ovary | 100% | 1872.67 | 180 / 180 | 98% | 16.81 | 420 / 430 |
stomach | 100% | 3663.25 | 359 / 359 | 98% | 35.86 | 279 / 286 |
intestine | 100% | 3074.48 | 966 / 966 | 97% | 31.27 | 512 / 527 |
uterus | 100% | 2615.85 | 170 / 170 | 96% | 23.41 | 442 / 459 |
bladder | 100% | 2594.48 | 21 / 21 | 96% | 22.39 | 485 / 504 |
thymus | 100% | 3016.55 | 653 / 653 | 96% | 17.08 | 579 / 605 |
liver | 100% | 2744.72 | 226 / 226 | 96% | 22.61 | 388 / 406 |
adrenal gland | 100% | 2933.38 | 258 / 258 | 91% | 18.57 | 210 / 230 |
kidney | 100% | 1707.38 | 89 / 89 | 89% | 18.30 | 804 / 901 |
skin | 100% | 2952.63 | 1800 / 1809 | 89% | 25.31 | 420 / 472 |
blood vessel | 100% | 3201.71 | 1335 / 1335 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 15.02 | 1 / 1 |
adipose | 100% | 3179.38 | 1203 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 2885.82 | 802 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2149.29 | 240 / 241 | 0% | 0 | 0 / 0 |
heart | 97% | 1660.55 | 838 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 18.92 | 42 / 45 |
lymph node | 0% | 0 | 0 / 0 | 69% | 10.19 | 20 / 29 |
peripheral blood | 68% | 1319.12 | 631 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 51% | 6.24 | 41 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0005975 | Biological process | carbohydrate metabolic process |
GO_1904382 | Biological process | mannose trimming involved in glycoprotein ERAD pathway |
GO_0006986 | Biological process | response to unfolded protein |
GO_0006058 | Biological process | mannoprotein catabolic process |
GO_1904380 | Biological process | endoplasmic reticulum mannose trimming |
GO_0036503 | Biological process | ERAD pathway |
GO_0006486 | Biological process | protein glycosylation |
GO_0005788 | Cellular component | endoplasmic reticulum lumen |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0016020 | Cellular component | membrane |
GO_0044322 | Cellular component | endoplasmic reticulum quality control compartment |
GO_0004571 | Molecular function | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity |
GO_0005509 | Molecular function | calcium ion binding |
Gene name | EDEM3 |
Protein name | alpha-1,2-Mannosidase (EC 3.2.1.-) ER degradation-enhancing alpha-mannosidase-like protein 3 (EC 3.2.1.113) (Alpha-1,2-mannosidase EDEM3) ER degradation enhancing alpha-mannosidase like protein 3 |
Synonyms | C1orf22 |
Description | FUNCTION: Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans . May also participate in mannose trimming from all glycoproteins and not just misfolded ones targeted to ERAD . May have alpha 1,2-mannosidase activity (By similarity). . |
Accessions | ENST00000318130.13 [Q9BZQ6-1] A0A8I5KVE6 ENST00000367512.8 H0Y498 ENST00000685596.1 A0A8I5KTR7 ENST00000686225.1 Q9BZQ6 ENST00000692170.1 ENST00000687113.1 A0A8J8YX80 ENST00000686047.1 ENST00000685249.1 A0A8I5KSQ8 A0A8I5KWI4 A0A8I5KR65 A0A8I5KU04 ENST00000439962.1 |