E2F2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of E2F2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of E2F2 at tissue level.

III. Associated gene sets

GO_1990086Biological processlens fiber cell apoptotic process
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_1903671Biological processnegative regulation of sprouting angiogenesis
GO_0072332Biological processintrinsic apoptotic signaling pathway by p53 class mediator
GO_0006355Biological processregulation of DNA-templated transcription
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0051726Biological processregulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0035189Cellular componentRb-E2F complex
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0000785Cellular componentchromatin
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameE2F2
Protein nameTranscription factor E2F2 (E2F-2)
Synonyms
DescriptionFUNCTION: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.

AccessionsQ14209
ENST00000634683.2
ENST00000361729.3