DYNC1LI1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060627Biological processregulation of vesicle-mediated transport
GO_0051301Biological processcell division
GO_0061502Biological processearly endosome to recycling endosome transport
GO_0007018Biological processmicrotubule-based movement
GO_0090267Biological processpositive regulation of mitotic cell cycle spindle assembly checkpoint
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0030667Cellular componentsecretory granule membrane
GO_0005886Cellular componentplasma membrane
GO_0005874Cellular componentmicrotubule
GO_0000922Cellular componentspindle pole
GO_0016020Cellular componentmembrane
GO_0030666Cellular componentendocytic vesicle membrane
GO_0005813Cellular componentcentrosome
GO_0000776Cellular componentkinetochore
GO_0055038Cellular componentrecycling endosome membrane
GO_0005868Cellular componentcytoplasmic dynein complex
GO_0005829Cellular componentcytosol
GO_0101003Cellular componentficolin-1-rich granule membrane
GO_0019003Molecular functionGDP binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0005525Molecular functionGTP binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0045504Molecular functiondynein heavy chain binding

IV. Literature review

[source]
Gene nameDYNC1LI1
Protein nameCytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1)
Dynein light intermediate chain
SynonymsDNCLI1
DescriptionFUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) . .

FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. .

FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. .

FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. .

AccessionsC9JLW1
ENST00000432458.6
ENST00000424991.1
C9JGM7
Q9Y6G9
E9PHI6
ENST00000413350.5
ENST00000273130.9