DUSP10 | OmnibusX

Name	Number of supported studies	Average coverage
mast cell	15 studies	29% ± 12%	Explore
natural killer cell	9 studies	23% ± 9%	Explore
regulatory T cell	7 studies	21% ± 4%	Explore
oligodendrocyte	6 studies	24% ± 9%	Explore
gamma-delta T cell	4 studies	25% ± 2%	Explore
squamous epithelial cell	3 studies	36% ± 18%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	27% ± 7%	Explore
innate lymphoid cell	3 studies	22% ± 7%	Explore
granulocyte	3 studies	26% ± 8%	Explore
oligodendrocyte precursor cell	3 studies	27% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	18% ± 1%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DUSP10 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	1760.08	226 / 226	99%	34.88	402 / 406
breast	100%	830.98	458 / 459	98%	33.97	1094 / 1118
lung	99%	661.19	575 / 578	97%	25.81	1123 / 1155
intestine	98%	887.40	947 / 966	96%	17.67	508 / 527
pancreas	96%	669.95	316 / 328	98%	26.52	174 / 178
skin	100%	1728.54	1807 / 1809	93%	40.60	439 / 472
esophagus	97%	470.88	1408 / 1445	93%	19.09	171 / 183
bladder	95%	377.67	20 / 21	89%	24.68	451 / 504
thymus	97%	361.49	635 / 653	85%	11.97	516 / 605
uterus	84%	305.14	142 / 170	95%	27.96	437 / 459
prostate	96%	371.65	235 / 245	80%	9.34	401 / 502
stomach	79%	283.60	284 / 359	94%	16.78	270 / 286
adrenal gland	93%	381.50	241 / 258	78%	11.72	180 / 230
brain	92%	376.84	2429 / 2642	79%	12.17	556 / 705
kidney	61%	178.76	54 / 89	78%	10.34	701 / 901
ovary	48%	137.49	86 / 180	81%	15.22	350 / 430
lymph node	0%	0	0 / 0	100%	32.28	29 / 29
spleen	100%	458.14	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	24.22	1 / 1
adipose	99%	519.56	1190 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	23.86	44 / 45
muscle	95%	760.95	761 / 803	0%	0	0 / 0
blood vessel	84%	270.41	1124 / 1335	0%	0	0 / 0
peripheral blood	82%	1233.02	760 / 929	0%	0	0 / 0
heart	76%	205.07	652 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	11%	1.34	9 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0048715	Biological process	negative regulation of oligodendrocyte differentiation
GO_0060266	Biological process	negative regulation of respiratory burst involved in inflammatory response
GO_0090335	Biological process	regulation of brown fat cell differentiation
GO_0070373	Biological process	negative regulation of ERK1 and ERK2 cascade
GO_0035970	Biological process	peptidyl-threonine dephosphorylation
GO_0035335	Biological process	peptidyl-tyrosine dephosphorylation
GO_0050680	Biological process	negative regulation of epithelial cell proliferation
GO_0002819	Biological process	regulation of adaptive immune response
GO_0043508	Biological process	negative regulation of JUN kinase activity
GO_0051403	Biological process	stress-activated MAPK cascade
GO_0032873	Biological process	negative regulation of stress-activated MAPK cascade
GO_1905042	Biological process	negative regulation of epithelium regeneration
GO_0046329	Biological process	negative regulation of JNK cascade
GO_0016311	Biological process	dephosphorylation
GO_0048709	Biological process	oligodendrocyte differentiation
GO_0030336	Biological process	negative regulation of cell migration
GO_0010633	Biological process	negative regulation of epithelial cell migration
GO_1990264	Biological process	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
GO_0045591	Biological process	positive regulation of regulatory T cell differentiation
GO_0032496	Biological process	response to lipopolysaccharide
GO_1903753	Biological process	negative regulation of p38MAPK cascade
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0008432	Molecular function	JUN kinase binding
GO_0017018	Molecular function	myosin phosphatase activity
GO_0048273	Molecular function	mitogen-activated protein kinase p38 binding
GO_0017017	Molecular function	MAP kinase tyrosine/serine/threonine phosphatase activity
GO_0033549	Molecular function	MAP kinase phosphatase activity
GO_0008330	Molecular function	protein tyrosine/threonine phosphatase activity
GO_0016791	Molecular function	phosphatase activity
GO_0033550	Molecular function	MAP kinase tyrosine phosphatase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	DUSP10
Protein name	Dual specificity protein phosphatase 10 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5) Dual specificity phosphatase 10 protein-serine/threonine phosphatase (EC 3.1.3.16)
Synonyms	MKP5
Description	FUNCTION: Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. .
Accessions	Q6IAR2 Q9Y6W6 ENST00000477026.5 ENST00000468085.5 A0A0B4J2F5 ENST00000366899.4 [Q9Y6W6-1] ENST00000494642.1

DUSP10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review