Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| ciliated cell | 14 studies | 30% ± 11% | |
| type I pneumocyte | 11 studies | 33% ± 9% | |
| type II pneumocyte | 11 studies | 42% ± 12% | |
| basal cell | 6 studies | 25% ± 6% | |
| epithelial cell | 5 studies | 30% ± 11% | |
| club cell | 5 studies | 22% ± 6% | |
| respiratory goblet cell | 4 studies | 25% ± 8% | |
| glutamatergic neuron | 3 studies | 24% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 20109.33 | 651 / 653 | 98% | 103.25 | 594 / 605 |
| lung | 95% | 19629.42 | 551 / 578 | 75% | 17.54 | 870 / 1155 |
| esophagus | 39% | 8785.29 | 557 / 1445 | 89% | 38.08 | 163 / 183 |
| prostate | 76% | 3649.75 | 186 / 245 | 43% | 4.07 | 216 / 502 |
| bladder | 43% | 2628.10 | 9 / 21 | 65% | 15.07 | 326 / 504 |
| adrenal gland | 79% | 3308.84 | 204 / 258 | 26% | 1.76 | 59 / 230 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 45.61 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 18.33 | 1 / 1 |
| stomach | 74% | 11121.16 | 266 / 359 | 22% | 2.28 | 63 / 286 |
| skin | 72% | 10004.15 | 1301 / 1809 | 17% | 3.32 | 78 / 472 |
| uterus | 6% | 445.37 | 10 / 170 | 79% | 27.24 | 364 / 459 |
| pancreas | 0% | 6.95 | 1 / 328 | 57% | 6.11 | 102 / 178 |
| breast | 2% | 31.47 | 7 / 459 | 31% | 2.97 | 344 / 1118 |
| ovary | 1% | 23.89 | 1 / 180 | 25% | 2.54 | 108 / 430 |
| intestine | 0% | 7.19 | 1 / 966 | 20% | 3.39 | 107 / 527 |
| eye | 0% | 0 | 0 / 0 | 20% | 1.92 | 16 / 80 |
| brain | 1% | 27.19 | 38 / 2642 | 11% | 0.77 | 80 / 705 |
| liver | 0% | 0 | 0 / 226 | 10% | 1.52 | 41 / 406 |
| kidney | 0% | 0 | 0 / 89 | 6% | 0.62 | 56 / 901 |
| heart | 1% | 25.73 | 12 / 861 | 0% | 0 | 0 / 0 |
| adipose | 1% | 22.80 | 8 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 1% | 12.55 | 8 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 0% | 2.51 | 1 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 4.34 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0042446 | Biological process | hormone biosynthetic process |
| GO_0006590 | Biological process | thyroid hormone generation |
| GO_0098869 | Biological process | cellular oxidant detoxification |
| GO_0042554 | Biological process | superoxide anion generation |
| GO_2000147 | Biological process | positive regulation of cell motility |
| GO_0042744 | Biological process | hydrogen peroxide catabolic process |
| GO_0051591 | Biological process | response to cAMP |
| GO_0050665 | Biological process | hydrogen peroxide biosynthetic process |
| GO_0042335 | Biological process | cuticle development |
| GO_0006979 | Biological process | response to oxidative stress |
| GO_0006952 | Biological process | defense response |
| GO_0090303 | Biological process | positive regulation of wound healing |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0043020 | Cellular component | NADPH oxidase complex |
| GO_0031252 | Cellular component | cell leading edge |
| GO_0009986 | Cellular component | cell surface |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0004601 | Molecular function | peroxidase activity |
| GO_0106294 | Molecular function | NADPH oxidase H202-forming activity |
| GO_0050661 | Molecular function | NADP binding |
| GO_0016174 | Molecular function | NAD(P)H oxidase H2O2-forming activity |
| GO_0020037 | Molecular function | heme binding |
| GO_0016175 | Molecular function | superoxide-generating NAD(P)H oxidase activity |
| GO_0106293 | Molecular function | NADH oxidase H202-forming activity |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | DUOX1 |
| Protein name | Dual oxidase 1 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 1) (Long NOX 1) (NADPH thyroid oxidase 1) (Thyroid oxidase 1) Dual oxidase 1 NAD(P)H oxidase (H2O2-forming) (EC 1.6.3.1) Alternative protein DUOX1 |
| Synonyms | DUOX LNOX1 THOX1 |
| Description | FUNCTION: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. . FUNCTION: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. . |
| Accessions | ENST00000321429.8 [Q9NRD9-1] Q14C85 ENST00000682390.1 H0YK19 ENST00000561220.6 ENST00000558322.5 ENST00000389037.7 [Q9NRD9-1] ENST00000561166.1 [Q9NRD9-2] H0YNR5 L8ECP1 A0A5P9KEJ7 A0A804HKN9 Q9NRD9 |
