DTX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0016567Biological processprotein ubiquitination
GO_0007219Biological processNotch signaling pathway
GO_0045581Biological processnegative regulation of T cell differentiation
GO_0010001Biological processglial cell differentiation
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0008593Biological processregulation of Notch signaling pathway
GO_0007166Biological processcell surface receptor signaling pathway
GO_0030217Biological processT cell differentiation
GO_0006351Biological processDNA-templated transcription
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005112Molecular functionNotch binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0008270Molecular functionzinc ion binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameDTX1
Protein nameE3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (Protein deltex-1) (Deltex1) (hDTX1) (RING-type E3 ubiquitin transferase DTX1)
Synonyms
DescriptionFUNCTION: Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. .

AccessionsQ86Y01
ENST00000257600.3
ENST00000548759.2