Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte precursor cell | 9 studies | 28% ± 13% | |
endothelial cell | 8 studies | 25% ± 13% | |
astrocyte | 7 studies | 33% ± 15% | |
interneuron | 6 studies | 32% ± 20% | |
epithelial cell | 5 studies | 24% ± 9% | |
GABAergic neuron | 5 studies | 40% ± 19% | |
macrophage | 4 studies | 23% ± 6% | |
microglial cell | 4 studies | 24% ± 6% | |
glutamatergic neuron | 4 studies | 54% ± 18% | |
oligodendrocyte | 4 studies | 27% ± 8% | |
neuron | 3 studies | 28% ± 7% | |
endothelial cell of lymphatic vessel | 3 studies | 20% ± 2% | |
transit amplifying cell | 3 studies | 29% ± 18% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 7 studies | 37% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2729.70 | 1445 / 1445 | 100% | 32.24 | 183 / 183 |
stomach | 100% | 2291.68 | 359 / 359 | 100% | 26.10 | 286 / 286 |
uterus | 100% | 3914.34 | 170 / 170 | 100% | 34.12 | 459 / 459 |
breast | 100% | 2906.85 | 459 / 459 | 100% | 34.11 | 1117 / 1118 |
intestine | 100% | 3083.90 | 966 / 966 | 100% | 26.16 | 526 / 527 |
prostate | 100% | 3312.99 | 245 / 245 | 100% | 25.07 | 501 / 502 |
skin | 100% | 3279.50 | 1809 / 1809 | 100% | 36.53 | 471 / 472 |
ovary | 100% | 4039.20 | 180 / 180 | 100% | 31.31 | 429 / 430 |
brain | 100% | 2923.20 | 2639 / 2642 | 100% | 34.59 | 704 / 705 |
bladder | 100% | 2966.00 | 21 / 21 | 100% | 29.02 | 502 / 504 |
thymus | 100% | 3769.26 | 653 / 653 | 99% | 22.29 | 601 / 605 |
lung | 100% | 2450.54 | 576 / 578 | 100% | 34.60 | 1151 / 1155 |
pancreas | 99% | 1872.45 | 326 / 328 | 99% | 21.63 | 177 / 178 |
kidney | 100% | 2423.19 | 89 / 89 | 99% | 19.53 | 888 / 901 |
adrenal gland | 100% | 2683.27 | 258 / 258 | 97% | 20.80 | 224 / 230 |
liver | 100% | 1142.04 | 226 / 226 | 94% | 13.24 | 382 / 406 |
adipose | 100% | 2726.01 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 39.97 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 22.02 | 29 / 29 |
spleen | 100% | 3053.80 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 28.65 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 10.87 | 1 / 1 |
blood vessel | 100% | 2776.18 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 2056.12 | 802 / 803 | 0% | 0 | 0 / 0 |
heart | 97% | 1764.90 | 835 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 65% | 1305.85 | 608 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0050829 | Biological process | defense response to Gram-negative bacterium |
GO_0010628 | Biological process | positive regulation of gene expression |
GO_0050727 | Biological process | regulation of inflammatory response |
GO_0031054 | Biological process | pre-miRNA processing |
GO_0050830 | Biological process | defense response to Gram-positive bacterium |
GO_0045589 | Biological process | regulation of regulatory T cell differentiation |
GO_2000628 | Biological process | regulation of miRNA metabolic process |
GO_0006364 | Biological process | rRNA processing |
GO_0010586 | Biological process | miRNA metabolic process |
GO_0031053 | Biological process | primary miRNA processing |
GO_0005730 | Cellular component | nucleolus |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0070877 | Cellular component | microprocessor complex |
GO_0005634 | Cellular component | nucleus |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0014069 | Cellular component | postsynaptic density |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0070412 | Molecular function | R-SMAD binding |
GO_0004525 | Molecular function | ribonuclease III activity |
GO_0046332 | Molecular function | SMAD binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0017151 | Molecular function | DEAD/H-box RNA helicase binding |
GO_0003723 | Molecular function | RNA binding |
GO_0070878 | Molecular function | primary miRNA binding |
GO_0001530 | Molecular function | lipopolysaccharide binding |
GO_0005515 | Molecular function | protein binding |
Gene name | DROSHA |
Protein name | Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241) Drosha ribonuclease III |
Synonyms | RN3 RNASEN RNASE3L |
Description | FUNCTION: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. . |
Accessions | H7C5U6 E5RHD1 ENST00000512302.1 ENST00000512076.1 ENST00000513349.5 [Q9NRR4-4] ENST00000511367.6 [Q9NRR4-1] Q9NRR4 ENST00000344624.8 [Q9NRR4-1] ENST00000507438.5 H0YB67 |