DROSHA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0010628Biological processpositive regulation of gene expression
GO_0050727Biological processregulation of inflammatory response
GO_0031054Biological processpre-miRNA processing
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0045589Biological processregulation of regulatory T cell differentiation
GO_2000628Biological processregulation of miRNA metabolic process
GO_0006364Biological processrRNA processing
GO_0010586Biological processmiRNA metabolic process
GO_0031053Biological processprimary miRNA processing
GO_0005730Cellular componentnucleolus
GO_0098978Cellular componentglutamatergic synapse
GO_0070877Cellular componentmicroprocessor complex
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0042803Molecular functionprotein homodimerization activity
GO_0070412Molecular functionR-SMAD binding
GO_0004525Molecular functionribonuclease III activity
GO_0046332Molecular functionSMAD binding
GO_0046872Molecular functionmetal ion binding
GO_0017151Molecular functionDEAD/H-box RNA helicase binding
GO_0003723Molecular functionRNA binding
GO_0070878Molecular functionprimary miRNA binding
GO_0001530Molecular functionlipopolysaccharide binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDROSHA
Protein nameRibonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241)
Drosha ribonuclease III
SynonymsRN3
RNASEN
RNASE3L
DescriptionFUNCTION: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. .

AccessionsH7C5U6
E5RHD1
ENST00000512302.1
ENST00000512076.1
ENST00000513349.5 [Q9NRR4-4]
ENST00000511367.6 [Q9NRR4-1]
Q9NRR4
ENST00000344624.8 [Q9NRR4-1]
ENST00000507438.5
H0YB67