DPM2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031647Biological processregulation of protein stability
GO_0019348Biological processdolichol metabolic process
GO_0006506Biological processGPI anchor biosynthetic process
GO_0035269Biological processprotein O-linked mannosylation
GO_0000506Cellular componentglycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
GO_0033185Cellular componentdolichol-phosphate-mannose synthase complex
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0008047Molecular functionenzyme activator activity
GO_0030234Molecular functionenzyme regulator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDPM2
Protein nameDolichol phosphate-mannose biosynthesis regulatory protein (Dolichol-phosphate mannose synthase subunit 2) (DPM synthase subunit 2)
Dolichol phosphate-mannose biosynthesis regulatory protein
SynonymsMy026
DescriptionFUNCTION: Regulates the biosynthesis of dolichol phosphate-mannose . Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1 . Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis . May act by regulating the GPI-GNT complex . .

FUNCTION: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. .

FUNCTION: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. .

AccessionsQ5T9C7
Q96BP5
ENST00000373110.4
ENST00000314392.13
O94777