Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell of lymphatic vessel | 12 studies | 24% ± 8% | |
| erythrocyte | 9 studies | 36% ± 11% | |
| glutamatergic neuron | 8 studies | 42% ± 21% | |
| platelet | 7 studies | 39% ± 12% | |
| neuron | 4 studies | 28% ± 8% | |
| retinal ganglion cell | 4 studies | 73% ± 26% | |
| GABAergic neuron | 4 studies | 40% ± 11% | |
| endothelial cell | 3 studies | 25% ± 10% | |
| retina horizontal cell | 3 studies | 19% ± 2% | |
| megakaryocyte | 3 studies | 36% ± 22% | |
| interneuron | 3 studies | 33% ± 14% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 6 studies | 32% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 100% | 6258.64 | 89 / 89 | 99% | 69.67 | 888 / 901 |
| thymus | 99% | 4399.17 | 645 / 653 | 97% | 46.93 | 587 / 605 |
| prostate | 90% | 2664.07 | 220 / 245 | 99% | 40.29 | 499 / 502 |
| brain | 97% | 17541.33 | 2552 / 2642 | 92% | 50.23 | 651 / 705 |
| adrenal gland | 91% | 2685.81 | 236 / 258 | 92% | 98.63 | 211 / 230 |
| intestine | 81% | 2523.89 | 785 / 966 | 97% | 35.11 | 511 / 527 |
| stomach | 72% | 1561.56 | 257 / 359 | 95% | 35.70 | 271 / 286 |
| esophagus | 74% | 3693.50 | 1073 / 1445 | 90% | 28.55 | 164 / 183 |
| lung | 74% | 1794.81 | 428 / 578 | 87% | 27.16 | 1010 / 1155 |
| pancreas | 60% | 1329.68 | 198 / 328 | 94% | 35.36 | 167 / 178 |
| breast | 75% | 1973.68 | 346 / 459 | 71% | 16.83 | 798 / 1118 |
| uterus | 43% | 883.73 | 73 / 170 | 78% | 22.02 | 356 / 459 |
| liver | 45% | 1145.89 | 101 / 226 | 74% | 22.60 | 301 / 406 |
| skin | 58% | 1510.17 | 1045 / 1809 | 60% | 14.23 | 284 / 472 |
| bladder | 29% | 558.33 | 6 / 21 | 73% | 19.90 | 366 / 504 |
| ureter | 0% | 0 | 0 / 0 | 100% | 12.24 | 1 / 1 |
| eye | 0% | 0 | 0 / 0 | 99% | 32.97 | 79 / 80 |
| muscle | 93% | 3152.55 | 749 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 91% | 3649.40 | 1221 / 1335 | 0% | 0 | 0 / 0 |
| ovary | 0% | 0 | 0 / 180 | 90% | 31.10 | 388 / 430 |
| heart | 90% | 4403.14 | 775 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 25.44 | 37 / 45 |
| peripheral blood | 81% | 14325.56 | 753 / 929 | 0% | 0 | 0 / 0 |
| adipose | 72% | 1910.09 | 868 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 49% | 1277.13 | 119 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.34 | 1 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
| GO_0051489 | Biological process | regulation of filopodium assembly |
| GO_0071786 | Biological process | endoplasmic reticulum tubular network organization |
| GO_0048821 | Biological process | erythrocyte development |
| GO_0030032 | Biological process | lamellipodium assembly |
| GO_0010763 | Biological process | positive regulation of fibroblast migration |
| GO_0051895 | Biological process | negative regulation of focal adhesion assembly |
| GO_0051693 | Biological process | actin filament capping |
| GO_0007010 | Biological process | cytoskeleton organization |
| GO_0051563 | Biological process | smooth endoplasmic reticulum calcium ion homeostasis |
| GO_0065003 | Biological process | protein-containing complex assembly |
| GO_0071277 | Biological process | cellular response to calcium ion |
| GO_0050732 | Biological process | negative regulation of peptidyl-tyrosine phosphorylation |
| GO_0051017 | Biological process | actin filament bundle assembly |
| GO_0010801 | Biological process | negative regulation of peptidyl-threonine phosphorylation |
| GO_0030036 | Biological process | actin cytoskeleton organization |
| GO_0071320 | Biological process | cellular response to cAMP |
| GO_0090315 | Biological process | negative regulation of protein targeting to membrane |
| GO_0030194 | Biological process | positive regulation of blood coagulation |
| GO_1900025 | Biological process | negative regulation of substrate adhesion-dependent cell spreading |
| GO_0008360 | Biological process | regulation of cell shape |
| GO_0033137 | Biological process | negative regulation of peptidyl-serine phosphorylation |
| GO_0010812 | Biological process | negative regulation of cell-substrate adhesion |
| GO_0010591 | Biological process | regulation of lamellipodium assembly |
| GO_0090303 | Biological process | positive regulation of wound healing |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0031410 | Cellular component | cytoplasmic vesicle |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005790 | Cellular component | smooth endoplasmic reticulum |
| GO_0005884 | Cellular component | actin filament |
| GO_0014731 | Cellular component | spectrin-associated cytoskeleton |
| GO_0030863 | Cellular component | cortical cytoskeleton |
| GO_0015629 | Cellular component | actin cytoskeleton |
| GO_0005829 | Cellular component | cytosol |
| GO_0014069 | Cellular component | postsynaptic density |
| GO_0031253 | Cellular component | cell projection membrane |
| GO_0031095 | Cellular component | platelet dense tubular network membrane |
| GO_0030507 | Molecular function | spectrin binding |
| GO_0051015 | Molecular function | actin filament binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0003779 | Molecular function | actin binding |
| Gene name | DMTN |
| Protein name | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) Dematin actin binding protein |
| Synonyms | DMT EPB49 |
| Description | FUNCTION: Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. . |
| Accessions | ENST00000523782.6 [Q08495-3] ENST00000519907.5 [Q08495-2] E5RFK4 ENST00000358242.6 [Q08495-1] A0A979HLS0 E5RGQ0 E5RJ61 ENST00000517418.5 E5RJC0 ENST00000520174.5 ENST00000523623.5 E5RFK6 Q08495 E5RGQ7 ENST00000443491.6 [Q08495-3] ENST00000517804.5 ENST00000517305.5 [Q08495-1] A0A087WT94 ENST00000519333.6 ENST00000519850.5 ENST00000265800.9 [Q08495-1] ENST00000381470.7 [Q08495-2] ENST00000415253.5 [Q08495-2] ENST00000517600.5 [Q08495-4] ENST00000522340.5 ENST00000523300.5 ENST00000523266.5 [Q08495-1] A0A087WUC0 ENST00000522148.5 ENST00000432128.6 [Q08495-1] |
