Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| type II pneumocyte | 10 studies | 25% ± 11% | |
| enterocyte | 5 studies | 24% ± 8% | |
| duct epithelial cell | 3 studies | 47% ± 21% | |
| intestinal crypt stem cell | 3 studies | 37% ± 12% | |
| transit amplifying cell | 3 studies | 44% ± 22% | |
| progenitor cell | 3 studies | 24% ± 12% | |
| epithelial cell | 3 studies | 44% ± 16% |
Insufficient scRNA-seq data for expression of DMBT1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 91% | 7174.70 | 526 / 578 | 62% | 64.30 | 721 / 1155 |
| pancreas | 77% | 329.04 | 252 / 328 | 75% | 89.19 | 134 / 178 |
| intestine | 62% | 15232.73 | 595 / 966 | 74% | 133.89 | 388 / 527 |
| stomach | 26% | 99.25 | 92 / 359 | 78% | 170.45 | 222 / 286 |
| bladder | 52% | 314.19 | 11 / 21 | 27% | 39.66 | 135 / 504 |
| esophagus | 13% | 103.72 | 194 / 1445 | 48% | 195.18 | 88 / 183 |
| prostate | 56% | 541.87 | 138 / 245 | 1% | 0.04 | 3 / 502 |
| brain | 40% | 82.50 | 1053 / 2642 | 0% | 0.02 | 1 / 705 |
| uterus | 15% | 94.94 | 25 / 170 | 19% | 10.40 | 86 / 459 |
| ovary | 7% | 20.68 | 13 / 180 | 15% | 5.26 | 65 / 430 |
| breast | 21% | 84.93 | 95 / 459 | 1% | 2.02 | 14 / 1118 |
| muscle | 20% | 59.21 | 158 / 803 | 0% | 0 | 0 / 0 |
| liver | 13% | 20.07 | 30 / 226 | 5% | 2.67 | 19 / 406 |
| skin | 11% | 15.20 | 205 / 1809 | 2% | 1.83 | 9 / 472 |
| thymus | 9% | 9.26 | 57 / 653 | 1% | 0.12 | 8 / 605 |
| adrenal gland | 3% | 13.16 | 8 / 258 | 0% | 0.07 | 1 / 230 |
| adipose | 3% | 4.30 | 41 / 1204 | 0% | 0 | 0 / 0 |
| kidney | 3% | 1.87 | 3 / 89 | 0% | 0 | 0 / 901 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.30 | 1 / 45 |
| peripheral blood | 1% | 3.88 | 11 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 1% | 4.50 | 15 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 1% | 1.98 | 2 / 241 | 0% | 0 | 0 / 0 |
| heart | 1% | 1.77 | 7 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0030855 | Biological process | epithelial cell differentiation |
| GO_0045087 | Biological process | innate immune response |
| GO_0050829 | Biological process | defense response to Gram-negative bacterium |
| GO_0051607 | Biological process | defense response to virus |
| GO_0016192 | Biological process | vesicle-mediated transport |
| GO_0050830 | Biological process | defense response to Gram-positive bacterium |
| GO_0015031 | Biological process | protein transport |
| GO_0043152 | Biological process | induction of bacterial agglutination |
| GO_0006952 | Biological process | defense response |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0031012 | Cellular component | extracellular matrix |
| GO_0042589 | Cellular component | zymogen granule membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0030670 | Cellular component | phagocytic vesicle membrane |
| GO_0038187 | Molecular function | pattern recognition receptor activity |
| GO_0005044 | Molecular function | scavenger receptor activity |
| GO_0048306 | Molecular function | calcium-dependent protein binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0035375 | Molecular function | zymogen binding |
| Gene name | DMBT1 |
| Protein name | Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) Deleted in malignant brain tumors 1 Deleted in malignant brain tumors 1 protein (Hensin) Alternative protein DMBT1 |
| Synonyms | GP340 |
| Description | FUNCTION: May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell. . |
| Accessions | ENST00000330163.8 [Q9UGM3-2] ENST00000664692.1 [Q9UGM3-7] A0A590UJ76 ENST00000619379.1 [Q9UGM3-1] A0A590UK99 ENST00000338354.10 [Q9UGM3-6] ENST00000368956.6 [Q9UGM3-2] A0A590UJF8 ENST00000653442.1 [Q9UGM3-5] ENST00000368955.7 [Q9UGM3-3] ENST00000652446.2 [Q9UGM3-1] ENST00000668486.1 ENST00000368909.7 [Q9UGM3-1] ENST00000666315.1 A0A590UIX5 A0A590UJZ9 B6V682 ENST00000664974.1 ENST00000344338.7 [Q9UGM3-3] ENST00000657942.1 [Q9UGM3-9] ENST00000656203.1 L8E969 ENST00000664003.1 Q9UGM3 |
