DLD | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	8 studies	26% ± 6%	Explore
epithelial cell	7 studies	35% ± 12%	Explore
basal cell	6 studies	28% ± 11%	Explore
fibroblast	6 studies	23% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	17% ± 1%	Explore
epithelial cell of proximal tubule	4 studies	22% ± 3%	Explore
kidney loop of Henle epithelial cell	4 studies	24% ± 5%	Explore
renal alpha-intercalated cell	4 studies	37% ± 6%	Explore
adipocyte	4 studies	19% ± 7%	Explore
erythroblast	4 studies	27% ± 14%	Explore
macrophage	4 studies	19% ± 3%	Explore
glutamatergic neuron	4 studies	43% ± 15%	Explore
natural killer cell	4 studies	18% ± 2%	Explore
hematopoietic precursor cell	3 studies	25% ± 11%	Explore
ionocyte	3 studies	26% ± 3%	Explore
CD4-positive, alpha-beta T cell	3 studies	18% ± 0%	Explore
classical monocyte	3 studies	21% ± 3%	Explore
non-classical monocyte	3 studies	26% ± 7%	Explore
smooth muscle cell	3 studies	18% ± 2%	Explore
ciliated cell	3 studies	31% ± 4%	Explore
rod bipolar cell	3 studies	16% ± 0%	Explore
secretory cell	3 studies	23% ± 7%	Explore
GABAergic neuron	3 studies	41% ± 7%	Explore
dendritic cell	3 studies	32% ± 10%	Explore
goblet cell	3 studies	20% ± 1%	Explore
intestinal crypt stem cell	3 studies	24% ± 6%	Explore
transit amplifying cell	3 studies	25% ± 6%	Explore
interneuron	3 studies	35% ± 18%	Explore
astrocyte	3 studies	25% ± 4%	Explore
oligodendrocyte	3 studies	17% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5723.20	1445 / 1445	100%	54.29	183 / 183
stomach	100%	4926.08	359 / 359	100%	58.91	286 / 286
intestine	100%	6198.20	966 / 966	100%	66.62	526 / 527
uterus	100%	3058.26	170 / 170	100%	50.54	458 / 459
ovary	100%	2480.24	180 / 180	100%	37.21	428 / 430
breast	100%	4244.49	459 / 459	99%	61.17	1112 / 1118
bladder	100%	4061.43	21 / 21	99%	57.17	501 / 504
kidney	100%	5780.39	89 / 89	99%	76.30	895 / 901
liver	100%	3699.44	226 / 226	99%	45.55	403 / 406
lung	99%	3115.61	573 / 578	100%	53.32	1155 / 1155
thymus	100%	3308.98	651 / 653	99%	46.13	601 / 605
prostate	100%	2814.78	244 / 245	99%	53.43	499 / 502
brain	98%	3206.63	2595 / 2642	100%	63.14	705 / 705
pancreas	98%	2243.28	321 / 328	100%	42.74	178 / 178
skin	100%	4126.39	1808 / 1809	98%	67.68	461 / 472
adrenal gland	100%	8854.63	258 / 258	97%	56.17	224 / 230
adipose	100%	4718.36	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	56.86	29 / 29
muscle	100%	10230.92	803 / 803	0%	0	0 / 0
spleen	100%	3274.72	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	54.32	45 / 45
ureter	0%	0	0 / 0	100%	11.01	1 / 1
blood vessel	100%	3154.67	1333 / 1335	0%	0	0 / 0
heart	98%	9399.96	846 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	93%	33.48	74 / 80
peripheral blood	68%	2594.15	629 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0042391	Biological process	regulation of membrane potential
GO_0006120	Biological process	mitochondrial electron transport, NADH to ubiquinone
GO_0048240	Biological process	sperm capacitation
GO_0007369	Biological process	gastrulation
GO_0009083	Biological process	branched-chain amino acid catabolic process
GO_0006086	Biological process	acetyl-CoA biosynthetic process from pyruvate
GO_0006508	Biological process	proteolysis
GO_0045254	Cellular component	pyruvate dehydrogenase complex
GO_0043159	Cellular component	acrosomal matrix
GO_0005739	Cellular component	mitochondrion
GO_0031514	Cellular component	motile cilium
GO_0045252	Cellular component	oxoglutarate dehydrogenase complex
GO_0005759	Cellular component	mitochondrial matrix
GO_1902493	Cellular component	acetyltransferase complex
GO_0005634	Cellular component	nucleus
GO_0034604	Molecular function	pyruvate dehydrogenase (NAD+) activity
GO_0050660	Molecular function	flavin adenine dinucleotide binding
GO_0004148	Molecular function	dihydrolipoyl dehydrogenase activity
GO_0047101	Molecular function	branched-chain alpha-keto acid dehydrogenase activity
GO_0005515	Molecular function	protein binding

Gene name	DLD
Protein name	dihydrolipoyl dehydrogenase (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) Dihydrolipoyl dehydrogenase (EC 1.8.1.4) Dihydrolipoamide dehydrogenase
Synonyms	LAD PHE3 GCSL
Description	FUNCTION: Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) . The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion . A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A . In monomeric form may have additional moonlighting function as serine protease . Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity). .
Accessions	ENST00000450038.5 P09622 F2Z2E3 ENST00000205402.10 [P09622-1] ENST00000437604.6 [P09622-3] ENST00000415325.5 ENST00000451081.5 F8WDY5 ENST00000417551.5 [P09622-1] ENST00000440410.5 F8WDM5 E9PEX6

DLD report