Name | Number of supported studies | Average coverage | |
---|---|---|---|
ciliated cell | 16 studies | 36% ± 13% | |
oligodendrocyte | 12 studies | 27% ± 11% | |
club cell | 11 studies | 38% ± 16% | |
type I pneumocyte | 10 studies | 46% ± 18% | |
type II pneumocyte | 10 studies | 57% ± 23% | |
basal cell | 9 studies | 36% ± 11% | |
epithelial cell | 9 studies | 30% ± 10% | |
ionocyte | 6 studies | 36% ± 11% | |
respiratory goblet cell | 6 studies | 40% ± 14% | |
endothelial cell | 6 studies | 26% ± 8% | |
secretory cell | 5 studies | 42% ± 6% | |
hepatocyte | 5 studies | 69% ± 20% | |
goblet cell | 5 studies | 23% ± 13% | |
retinal ganglion cell | 4 studies | 75% ± 22% | |
luminal hormone-sensing cell of mammary gland | 4 studies | 27% ± 9% | |
luminal cell of prostate epithelium | 4 studies | 26% ± 9% | |
GABAergic neuron | 4 studies | 24% ± 8% | |
duct epithelial cell | 3 studies | 38% ± 15% | |
neuron | 3 studies | 24% ± 4% | |
squamous epithelial cell | 3 studies | 42% ± 14% | |
endothelial cell of sinusoid | 3 studies | 23% ± 4% | |
glutamatergic neuron | 3 studies | 43% ± 9% | |
pancreatic ductal cell | 3 studies | 42% ± 16% | |
abnormal cell | 3 studies | 29% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
liver | 100% | 58499.77 | 226 / 226 | 99% | 562.93 | 401 / 406 |
lung | 92% | 25651.71 | 529 / 578 | 94% | 277.35 | 1088 / 1155 |
prostate | 86% | 13696.01 | 210 / 245 | 99% | 528.62 | 495 / 502 |
breast | 81% | 11905.80 | 370 / 459 | 96% | 424.38 | 1069 / 1118 |
stomach | 80% | 13792.55 | 288 / 359 | 78% | 108.26 | 224 / 286 |
adrenal gland | 100% | 213883.78 | 258 / 258 | 52% | 517.42 | 120 / 230 |
skin | 98% | 32613.79 | 1768 / 1809 | 54% | 76.74 | 256 / 472 |
esophagus | 43% | 19340.33 | 618 / 1445 | 93% | 200.37 | 170 / 183 |
ovary | 36% | 4163.47 | 65 / 180 | 97% | 291.91 | 416 / 430 |
intestine | 34% | 3942.90 | 326 / 966 | 91% | 130.38 | 479 / 527 |
brain | 76% | 12399.82 | 1998 / 2642 | 47% | 49.00 | 331 / 705 |
pancreas | 27% | 2010.94 | 89 / 328 | 79% | 101.85 | 140 / 178 |
kidney | 57% | 4503.25 | 51 / 89 | 48% | 49.29 | 436 / 901 |
spleen | 98% | 18909.62 | 237 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 266.72 | 44 / 45 |
uterus | 11% | 1336.71 | 19 / 170 | 86% | 229.99 | 397 / 459 |
bladder | 14% | 810.81 | 3 / 21 | 81% | 156.41 | 410 / 504 |
muscle | 89% | 22436.15 | 715 / 803 | 0% | 0 | 0 / 0 |
adipose | 67% | 7859.01 | 808 / 1204 | 0% | 0 | 0 / 0 |
thymus | 22% | 1591.74 | 143 / 653 | 8% | 6.24 | 50 / 605 |
blood vessel | 21% | 1517.26 | 280 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 18% | 2504.16 | 170 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 14% | 10.37 | 4 / 29 |
heart | 10% | 817.19 | 86 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 1% | 1.21 | 1 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007265 | Biological process | Ras protein signal transduction |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_0009888 | Biological process | tissue development |
GO_0061024 | Biological process | membrane organization |
GO_0033490 | Biological process | cholesterol biosynthetic process via lathosterol |
GO_0009725 | Biological process | response to hormone |
GO_0030539 | Biological process | male genitalia development |
GO_0008104 | Biological process | protein localization |
GO_0043588 | Biological process | skin development |
GO_0008202 | Biological process | steroid metabolic process |
GO_0006695 | Biological process | cholesterol biosynthetic process |
GO_0042987 | Biological process | amyloid precursor protein catabolic process |
GO_0031639 | Biological process | plasminogen activation |
GO_0033489 | Biological process | cholesterol biosynthetic process via desmosterol |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0000139 | Cellular component | Golgi membrane |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0019899 | Molecular function | enzyme binding |
GO_0000246 | Molecular function | delta24(24-1) sterol reductase activity |
GO_0071949 | Molecular function | FAD binding |
GO_0016628 | Molecular function | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor |
GO_0005515 | Molecular function | protein binding |
GO_0050614 | Molecular function | delta24-sterol reductase activity |
GO_0042605 | Molecular function | peptide antigen binding |
Gene name | DHCR24 |
Protein name | Delta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol Delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1) 24-dehydrocholesterol reductase |
Synonyms | KIAA0018 |
Description | FUNCTION: Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis . In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress . Also protects against amyloid-beta peptide-induced apoptosis . . |
Accessions | ENST00000649769.1 ENST00000436604.2 [Q15392-1] ENST00000648728.1 ENST00000535035.6 ENST00000647912.1 A0A3B3IT58 A0A0A0MTI1 ENST00000371269.9 [Q15392-1] A0A3B3ISR5 Q15392 A0A3B3IRV7 A0A3B3ITT9 ENST00000648182.1 ENST00000650362.1 |