DHCR24 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007265Biological processRas protein signal transduction
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0009888Biological processtissue development
GO_0061024Biological processmembrane organization
GO_0033490Biological processcholesterol biosynthetic process via lathosterol
GO_0009725Biological processresponse to hormone
GO_0030539Biological processmale genitalia development
GO_0008104Biological processprotein localization
GO_0043588Biological processskin development
GO_0008202Biological processsteroid metabolic process
GO_0006695Biological processcholesterol biosynthetic process
GO_0042987Biological processamyloid precursor protein catabolic process
GO_0031639Biological processplasminogen activation
GO_0033489Biological processcholesterol biosynthetic process via desmosterol
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0000246Molecular functiondelta24(24-1) sterol reductase activity
GO_0071949Molecular functionFAD binding
GO_0016628Molecular functionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO_0005515Molecular functionprotein binding
GO_0050614Molecular functiondelta24-sterol reductase activity
GO_0042605Molecular functionpeptide antigen binding

IV. Literature review

[source]
Gene nameDHCR24
Protein nameDelta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol Delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1)
24-dehydrocholesterol reductase
SynonymsKIAA0018
DescriptionFUNCTION: Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis . In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress . Also protects against amyloid-beta peptide-induced apoptosis . .

AccessionsENST00000649769.1
ENST00000436604.2 [Q15392-1]
ENST00000648728.1
ENST00000535035.6
ENST00000647912.1
A0A3B3IT58
A0A0A0MTI1
ENST00000371269.9 [Q15392-1]
A0A3B3ISR5
Q15392
A0A3B3IRV7
A0A3B3ITT9
ENST00000648182.1
ENST00000650362.1