DGKE report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006654Biological processphosphatidic acid biosynthetic process
GO_0046339Biological processdiacylglycerol metabolic process
GO_0007205Biological processprotein kinase C-activating G protein-coupled receptor signaling pathway
GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0030168Biological processplatelet activation
GO_0046834Biological processlipid phosphorylation
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0098978Cellular componentglutamatergic synapse
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0004143Molecular functionATP-dependent diacylglycerol kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity

IV. Literature review

[source]
Gene nameDGKE
Protein nameDiacylglycerol kinase epsilon (DAG kinase epsilon) (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon)
Diacylglycerol kinase epsilon
Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107)
SynonymsDAGK5
hCG_32229
DescriptionFUNCTION: Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids . Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes . Also plays an important role in the biosynthesis of complex lipids . Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle . Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently . .

AccessionsI3L112
P52429
I3L2V2
ENST00000572810.1 [P52429-2]
ENST00000284061.8 [P52429-1]
ENST00000572944.1
ENST00000570738.1
A1L4Q0