Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 15 studies | 26% ± 5% | |
glutamatergic neuron | 7 studies | 39% ± 24% | |
retinal rod cell | 7 studies | 26% ± 6% | |
retinal cone cell | 6 studies | 37% ± 13% | |
retinal bipolar neuron | 5 studies | 43% ± 11% | |
capillary endothelial cell | 4 studies | 18% ± 2% | |
GABAergic neuron | 4 studies | 57% ± 14% | |
oligodendrocyte precursor cell | 4 studies | 25% ± 7% | |
glomerular endothelial cell | 3 studies | 22% ± 1% | |
neuron | 3 studies | 21% ± 5% | |
endothelial cell of artery | 3 studies | 17% ± 2% | |
epithelial cell | 3 studies | 24% ± 7% | |
rod bipolar cell | 3 studies | 77% ± 6% | |
endothelial cell of vascular tree | 3 studies | 21% ± 7% | |
interneuron | 3 studies | 56% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 1700.53 | 245 / 245 | 99% | 4.47 | 496 / 502 |
thymus | 100% | 1702.36 | 652 / 653 | 99% | 4.30 | 597 / 605 |
esophagus | 100% | 1219.17 | 1442 / 1445 | 98% | 5.64 | 180 / 183 |
pancreas | 100% | 835.88 | 327 / 328 | 98% | 4.10 | 175 / 178 |
intestine | 100% | 1781.32 | 966 / 966 | 98% | 4.00 | 516 / 527 |
bladder | 100% | 1566.62 | 21 / 21 | 97% | 3.69 | 488 / 504 |
stomach | 100% | 1297.11 | 359 / 359 | 95% | 3.87 | 273 / 286 |
uterus | 100% | 2452.19 | 170 / 170 | 95% | 3.50 | 437 / 459 |
breast | 100% | 1257.43 | 459 / 459 | 95% | 4.92 | 1064 / 1118 |
lung | 100% | 2075.78 | 578 / 578 | 94% | 3.63 | 1088 / 1155 |
ovary | 100% | 1398.32 | 180 / 180 | 90% | 2.68 | 388 / 430 |
adrenal gland | 93% | 552.61 | 239 / 258 | 88% | 8.50 | 203 / 230 |
kidney | 99% | 902.70 | 88 / 89 | 79% | 2.70 | 715 / 901 |
brain | 99% | 2163.00 | 2623 / 2642 | 66% | 2.01 | 467 / 705 |
liver | 93% | 569.60 | 210 / 226 | 48% | 1.16 | 193 / 406 |
skin | 98% | 692.60 | 1769 / 1809 | 35% | 0.69 | 165 / 472 |
spleen | 100% | 2845.46 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 1321.06 | 1200 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1109.52 | 1330 / 1335 | 0% | 0 | 0 / 0 |
heart | 95% | 680.68 | 822 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 91% | 2.77 | 41 / 45 |
lymph node | 0% | 0 | 0 / 0 | 90% | 3.95 | 26 / 29 |
peripheral blood | 54% | 745.92 | 501 / 929 | 0% | 0 | 0 / 0 |
muscle | 32% | 130.23 | 257 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 24% | 0.80 | 19 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006654 | Biological process | phosphatidic acid biosynthetic process |
GO_0046339 | Biological process | diacylglycerol metabolic process |
GO_0007205 | Biological process | protein kinase C-activating G protein-coupled receptor signaling pathway |
GO_0050804 | Biological process | modulation of chemical synaptic transmission |
GO_0030168 | Biological process | platelet activation |
GO_0046834 | Biological process | lipid phosphorylation |
GO_0006661 | Biological process | phosphatidylinositol biosynthetic process |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0016020 | Cellular component | membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0004143 | Molecular function | ATP-dependent diacylglycerol kinase activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0016301 | Molecular function | kinase activity |
Gene name | DGKE |
Protein name | Diacylglycerol kinase epsilon (DAG kinase epsilon) (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon) Diacylglycerol kinase epsilon Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) |
Synonyms | DAGK5 hCG_32229 |
Description | FUNCTION: Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids . Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes . Also plays an important role in the biosynthesis of complex lipids . Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle . Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently . . |
Accessions | I3L112 P52429 I3L2V2 ENST00000572810.1 [P52429-2] ENST00000284061.8 [P52429-1] ENST00000572944.1 ENST00000570738.1 A1L4Q0 |