I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| goblet cell | 4 studies | 27% ± 11% | |
| intestinal crypt stem cell | 4 studies | 36% ± 17% | |
| enterocyte | 3 studies | 44% ± 26% | |
| paneth cell | 3 studies | 98% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| goblet cell | 4 studies | 27% ± 11% | |
| intestinal crypt stem cell | 4 studies | 36% ± 17% | |
| enterocyte | 3 studies | 44% ± 26% | |
| paneth cell | 3 studies | 98% ± 3% |
Insufficient scRNA-seq data for expression of DEFA5 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| intestine | 57% | 23875.32 | 554 / 966 | 41% | 399.59 | 215 / 527 |
| stomach | 36% | 8.24 | 130 / 359 | 27% | 90.59 | 78 / 286 |
| pancreas | 36% | 4.84 | 119 / 328 | 6% | 42.52 | 10 / 178 |
| spleen | 39% | 4.89 | 93 / 241 | 0% | 0 | 0 / 0 |
| liver | 38% | 6.43 | 85 / 226 | 1% | 1.64 | 3 / 406 |
| brain | 37% | 3.18 | 987 / 2642 | 0% | 0.02 | 1 / 705 |
| adrenal gland | 37% | 5.71 | 96 / 258 | 0% | 0 | 0 / 230 |
| prostate | 30% | 3.42 | 73 / 245 | 4% | 75.67 | 22 / 502 |
| esophagus | 29% | 18.47 | 412 / 1445 | 4% | 36.50 | 8 / 183 |
| ovary | 32% | 5.03 | 58 / 180 | 0% | 0.12 | 1 / 430 |
| lung | 24% | 6.82 | 137 / 578 | 4% | 77.65 | 41 / 1155 |
| thymus | 27% | 3.80 | 177 / 653 | 0% | 0 | 0 / 605 |
| peripheral blood | 27% | 10.05 | 248 / 929 | 0% | 0 | 0 / 0 |
| uterus | 25% | 3.80 | 42 / 170 | 1% | 358.77 | 6 / 459 |
| skin | 24% | 3.37 | 433 / 1809 | 0% | 0 | 0 / 472 |
| breast | 24% | 6.67 | 109 / 459 | 0% | 0.01 | 1 / 1118 |
| kidney | 24% | 2.01 | 21 / 89 | 0% | 0 | 0 / 901 |
| adipose | 23% | 3.20 | 275 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 22% | 4.35 | 293 / 1335 | 0% | 0 | 0 / 0 |
| heart | 21% | 2.72 | 180 / 861 | 0% | 0 | 0 / 0 |
| muscle | 19% | 1.91 | 150 / 803 | 0% | 0 | 0 / 0 |
| bladder | 5% | 0.86 | 1 / 21 | 14% | 126.51 | 70 / 504 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0050832 | Biological process | defense response to fungus |
| GO_1905710 | Biological process | positive regulation of membrane permeability |
| GO_0045087 | Biological process | innate immune response |
| GO_0019731 | Biological process | antibacterial humoral response |
| GO_0050829 | Biological process | defense response to Gram-negative bacterium |
| GO_0051673 | Biological process | disruption of plasma membrane integrity in another organism |
| GO_0031640 | Biological process | killing of cells of another organism |
| GO_0050830 | Biological process | defense response to Gram-positive bacterium |
| GO_0032757 | Biological process | positive regulation of interleukin-8 production |
| GO_0071222 | Biological process | cellular response to lipopolysaccharide |
| GO_0061844 | Biological process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| GO_0002227 | Biological process | innate immune response in mucosa |
| GO_0051873 | Biological process | killing by host of symbiont cells |
| GO_0051289 | Biological process | protein homotetramerization |
| GO_0005615 | Cellular component | extracellular space |
| GO_0030496 | Cellular component | midbody |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005796 | Cellular component | Golgi lumen |
| GO_0034774 | Cellular component | secretory granule lumen |
| GO_0030133 | Cellular component | transport vesicle |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0030141 | Cellular component | secretory granule |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | DEFA5 |
| Protein name | Defensin alpha 5 (Defensin-5) (HD5(20-94)) [Cleaved into: HD5(23-94); HD5(29-94); HD5(56-94); HD5(63-94)] |
| Synonyms | DEF5 |
| Description | FUNCTION: Host-defense peptide that maintains sterility in the urogenital system . Has antimicrobial activity against a wide range of bacteria, including Gram-negative E.coli, P.aeruginosa and S.typhimurium, and Gram-positive E.aerogenes, S.aureus, B.cereus, E.faecium and L.monocytogenes . Confers resistance to intestinal infection by S.typhimurium . Exhibits antimicrobial activity against enteric commensal bacteria such as B.adolescentis, L.acidophilus, B.breve, L.fermentum, B.longum and S.thermophilus . Binds to bacterial membranes and causes membrane disintegration . Induces the secretion of the chemokine IL-8 by intestinal epithelial cells . Binds to B.antracis lef/lethal factor, a major virulence factor from B.anthracis, and neutralizes its enzymatic activity . .; FUNCTION: (Microbial infection) Acts as a target for S.flexneri infection by binding to the bacterium, possibly via bacterial surface proteins, and thereby augmenting infectivity via enhanced bacterial adhesion and invasion of epithelial cells and tissues. . |
| Accessions | ENST00000330590.4 Q01523 ENST00000647159.2 |
