Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 16 studies | 24% ± 8% | |
fibroblast | 10 studies | 20% ± 5% | |
ciliated cell | 10 studies | 29% ± 11% | |
epithelial cell | 6 studies | 40% ± 16% | |
B cell | 5 studies | 17% ± 1% | |
endothelial cell of lymphatic vessel | 5 studies | 19% ± 4% | |
adipocyte | 5 studies | 19% ± 2% | |
astrocyte | 5 studies | 23% ± 8% | |
goblet cell | 5 studies | 26% ± 13% | |
pericyte | 5 studies | 19% ± 5% | |
macrophage | 5 studies | 23% ± 5% | |
smooth muscle cell | 4 studies | 18% ± 2% | |
type I pneumocyte | 4 studies | 19% ± 2% | |
abnormal cell | 4 studies | 21% ± 8% | |
neuron | 4 studies | 24% ± 6% | |
microglial cell | 4 studies | 22% ± 5% | |
myeloid cell | 4 studies | 21% ± 4% | |
basal cell | 4 studies | 38% ± 9% | |
glutamatergic neuron | 4 studies | 46% ± 18% | |
connective tissue cell | 4 studies | 18% ± 2% | |
mast cell | 3 studies | 17% ± 2% | |
secretory cell | 3 studies | 27% ± 10% | |
hematopoietic precursor cell | 3 studies | 24% ± 10% | |
club cell | 3 studies | 20% ± 4% | |
lymphocyte | 3 studies | 23% ± 4% | |
GABAergic neuron | 3 studies | 43% ± 5% | |
enteroendocrine cell | 3 studies | 18% ± 4% | |
transit amplifying cell | 3 studies | 34% ± 19% | |
oligodendrocyte | 3 studies | 22% ± 2% | |
oligodendrocyte precursor cell | 3 studies | 24% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 9945.00 | 21 / 21 | 100% | 50.68 | 504 / 504 |
breast | 100% | 10154.00 | 459 / 459 | 100% | 72.47 | 1118 / 1118 |
esophagus | 100% | 8947.18 | 1445 / 1445 | 100% | 45.11 | 183 / 183 |
intestine | 100% | 9790.65 | 966 / 966 | 100% | 43.09 | 527 / 527 |
pancreas | 100% | 7826.87 | 328 / 328 | 100% | 48.09 | 178 / 178 |
prostate | 100% | 9658.73 | 245 / 245 | 100% | 57.82 | 502 / 502 |
uterus | 100% | 10263.88 | 170 / 170 | 100% | 53.71 | 459 / 459 |
lung | 100% | 8757.86 | 578 / 578 | 100% | 54.01 | 1153 / 1155 |
thymus | 100% | 8888.89 | 653 / 653 | 100% | 52.65 | 602 / 605 |
skin | 100% | 10056.67 | 1809 / 1809 | 99% | 60.25 | 469 / 472 |
ovary | 100% | 11171.10 | 180 / 180 | 99% | 36.09 | 427 / 430 |
stomach | 100% | 7786.62 | 359 / 359 | 99% | 40.83 | 284 / 286 |
brain | 100% | 6556.85 | 2637 / 2642 | 99% | 68.78 | 701 / 705 |
kidney | 100% | 5719.70 | 89 / 89 | 99% | 42.07 | 889 / 901 |
liver | 100% | 3628.17 | 226 / 226 | 99% | 28.79 | 400 / 406 |
adrenal gland | 100% | 8397.69 | 258 / 258 | 97% | 43.96 | 224 / 230 |
adipose | 100% | 9961.54 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 9649.36 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 50.38 | 29 / 29 |
muscle | 100% | 7366.12 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 9204.77 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 47.65 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 23.80 | 1 / 1 |
heart | 98% | 4923.19 | 840 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 47.30 | 78 / 80 |
peripheral blood | 86% | 4438.50 | 796 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0008104 | Biological process | protein localization |
GO_0042981 | Biological process | regulation of apoptotic process |
GO_1903241 | Biological process | U2-type prespliceosome assembly |
GO_0015030 | Cellular component | Cajal body |
GO_0016607 | Cellular component | nuclear speck |
GO_0071004 | Cellular component | U2-type prespliceosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0016020 | Cellular component | membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005515 | Molecular function | protein binding |
GO_0003724 | Molecular function | RNA helicase activity |
GO_0016887 | Molecular function | ATP hydrolysis activity |
GO_0005524 | Molecular function | ATP binding |
GO_0003723 | Molecular function | RNA binding |
Gene name | DDX42 |
Protein name | DEAD-box helicase 42 ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) |
Synonyms | |
Description | FUNCTION: ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures . Unwinding is promoted in the presence of single-strand binding proteins . Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein . ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands . Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP . Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 . Relocalizes TP53BP2 to the cytoplasm . . |
Accessions | J3KRE3 ENST00000584261.5 J3KTK9 ENST00000577940.6 J3QRI2 ENST00000583590.5 [Q86XP3-1] ENST00000581135.5 J3KRV0 ENST00000389924.7 [Q86XP3-1] ENST00000578137.5 ENST00000359353.9 [Q86XP3-2] ENST00000578681.5 [Q86XP3-1] Q86XP3 |