DDX42 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008104Biological processprotein localization
GO_0042981Biological processregulation of apoptotic process
GO_1903241Biological processU2-type prespliceosome assembly
GO_0015030Cellular componentCajal body
GO_0016607Cellular componentnuclear speck
GO_0071004Cellular componentU2-type prespliceosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003724Molecular functionRNA helicase activity
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameDDX42
Protein nameDEAD-box helicase 42
ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125)
Synonyms
DescriptionFUNCTION: ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures . Unwinding is promoted in the presence of single-strand binding proteins . Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein . ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands . Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP . Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2 . Relocalizes TP53BP2 to the cytoplasm . .

AccessionsJ3KRE3
ENST00000584261.5
J3KTK9
ENST00000577940.6
J3QRI2
ENST00000583590.5 [Q86XP3-1]
ENST00000581135.5
J3KRV0
ENST00000389924.7 [Q86XP3-1]
ENST00000578137.5
ENST00000359353.9 [Q86XP3-2]
ENST00000578681.5 [Q86XP3-1]
Q86XP3