DDX11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0007062Biological processsister chromatid cohesion
GO_0006281Biological processDNA repair
GO_0034085Biological processestablishment of sister chromatid cohesion
GO_0006974Biological processDNA damage response
GO_0072711Biological processcellular response to hydroxyurea
GO_1904976Biological processcellular response to bleomycin
GO_1990700Biological processnucleolar chromatin organization
GO_0045876Biological processpositive regulation of sister chromatid cohesion
GO_0031297Biological processreplication fork processing
GO_0044806Biological processG-quadruplex DNA unwinding
GO_0035563Biological processpositive regulation of chromatin binding
GO_0032079Biological processpositive regulation of endodeoxyribonuclease activity
GO_1901838Biological processpositive regulation of transcription of nucleolar large rRNA by RNA polymerase I
GO_0032091Biological processnegative regulation of protein binding
GO_2000781Biological processpositive regulation of double-strand break repair
GO_0072719Biological processcellular response to cisplatin
GO_0005730Cellular componentnucleolus
GO_0030496Cellular componentmidbody
GO_0000922Cellular componentspindle pole
GO_0031390Cellular componentCtf18 RFC-like complex
GO_0005813Cellular componentcentrosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0030892Cellular componentmitotic cohesin complex
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0004386Molecular functionhelicase activity
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0003682Molecular functionchromatin binding
GO_0003688Molecular functionDNA replication origin binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0045142Molecular functiontriplex DNA binding
GO_0008186Molecular functionATP-dependent activity, acting on RNA
GO_0051880Molecular functionG-quadruplex DNA binding
GO_0003678Molecular functionDNA helicase activity
GO_0043139Molecular function5'-3' DNA helicase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0008094Molecular functionATP-dependent activity, acting on DNA
GO_0005515Molecular functionprotein binding
GO_0051539Molecular function4 iron, 4 sulfur cluster binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameDDX11
Protein nameDEAD/H-box helicase 11
DDX11 protein
DEAD/H-box helicase 11 (cDNA FLJ60129, highly similar to Probable ATP-dependent RNA helicase DDX11)
ATP-dependent DNA helicase DDX11 (EC 3.6.4.12) (CHL1-related protein 1) (hCHLR1) (DEAD/H-box protein 11) (Keratinocyte growth factor-regulated gene 2 protein) (KRG-2)
SynonymsCHL1
KRG2
CHLR1
DescriptionFUNCTION: DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis . Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction . The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended up to 500 bp by the replication protein A (RPA) or the cohesion CTF18-replication factor C (Ctf18-RFC) complex activities . Shows also ATPase- and helicase activities on substrates that mimic key DNA intermediates of replication, repair and homologous recombination reactions, including forked duplex, anti-parallel G-quadruplex and three-stranded D-loop DNA molecules . Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage . Recruited with TIMELESS factor upon DNA-replication stress response at DNA replication fork to preserve replication fork progression, and hence ensure DNA replication fidelity . Cooperates also with TIMELESS factor during DNA replication to regulate proper sister chromatid cohesion and mitotic chromosome segregation . Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner; and hence it may contribute in Okazaki fragment processing at DNA replication fork during lagging strand DNA synthesis . Its ability to function at DNA replication fork is modulated by its binding to long non-coding RNA (lncRNA) cohesion regulator non-coding RNA DDX11-AS1/CONCR, which is able to increase both DDX11 ATPase activity and binding to DNA replicating regions . Also plays a role in heterochromatin organization . Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery . Plays a role in embryonic development and prevention of aneuploidy (By similarity). Involved in melanoma cell proliferation and survival . Associates with chromatin at DNA replication fork regions . Binds to single- and double-stranded DNAs . .; FUNCTION: (Microbial infection) Required for bovine papillomavirus type 1 regulatory protein E2 loading onto mitotic chromosomes during DNA replication for the viral genome to be maintained and segregated. .

AccessionsENST00000544652.1
ENST00000545115.5
ENST00000545668.5 [Q96FC9-1]
ENST00000438391.6
ENST00000540935.5
F5GYY1
Q2NKM7
ENST00000350437.8 [Q96FC9-4]
F5H235
ENST00000542838.6 [Q96FC9-2]
ENST00000535317.5
H0YFY8
F6WZM0
ENST00000539702.1
F5GXL6
H0YGL4
ENST00000543756.5
F5GXJ8
Q96FC9
ENST00000435753.6 [Q96FC9-5]
ENST00000538345.1
ENST00000542244.5
ENST00000539049.5
ENST00000542129.5
ENST00000228264.10 [Q96FC9-3]
F5H2V9
C9K0E8
B4DMS8
H0YGX9
R4GNE1
ENST00000415475.6