DDHD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090141Biological processpositive regulation of mitochondrial fission
GO_0046488Biological processphosphatidylinositol metabolic process
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0004620Molecular functionphospholipase activity
GO_0008970Molecular functionphospholipase A1 activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameDDHD1
Protein namePhospholipase DDHD1 (EC 3.1.1.111) (EC 3.1.1.32) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1) (EC 3.1.1.118) (Phospholipid sn-1 acylhydrolase)
DDHD domain containing 1
SynonymsKIAA1705
DescriptionFUNCTION: Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (Probable). Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (Probable). Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system. Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity). Regulates mitochondrial morphology . These dynamic changes may be due to PA hydrolysis at the mitochondrial surface . May play a regulatory role in spermatogenesis or sperm function . .

AccessionsA0A669KAW5
A0A669KB51
Q8NEL9
ENST00000673822.2 [Q8NEL9-1]
A0A6E1W401
G3V2P6
ENST00000674152.1
ENST00000357758.3 [Q8NEL9-2]
ENST00000673930.1
ENST00000674014.1
ENST00000323669.10
A0A669KB64
ENST00000395606.5 [Q8NEL9-4]
ENST00000556910.1