DDB2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DDB2 at tissue level.

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0000209Biological processprotein polyubiquitination
GO_0034644Biological processcellular response to UV
GO_0006289Biological processnucleotide-excision repair
GO_0070914Biological processUV-damage excision repair
GO_0006974Biological processDNA damage response
GO_0051865Biological processprotein autoubiquitination
GO_0009411Biological processresponse to UV
GO_0006290Biological processpyrimidine dimer repair
GO_0031464Cellular componentCul4A-RING E3 ubiquitin ligase complex
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0080008Cellular componentCul4-RING E3 ubiquitin ligase complex
GO_0090734Cellular componentsite of DNA damage
GO_0031465Cellular componentCul4B-RING E3 ubiquitin ligase complex
GO_0030054Cellular componentcell junction
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameDDB2
Protein nameDamage-specific DNA-binding protein 2
DNA damage-binding protein 2 (DDB p48 subunit) (DDBb) (Damage-specific DNA-binding protein 2) (UV-damaged DNA-binding protein 2) (UV-DDB 2)
Damage specific DNA binding protein 2
Synonyms
DescriptionFUNCTION: Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively . Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair . The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches . Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1) . The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage . The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair . The DDB2-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER . The DDB2-CUL4-ROC1 complex also ubiquitinates KAT7/HBO1 in response to DNA damage, leading to its degradation: recognizes KAT7/HBO1 following phosphorylation by ATR . .; FUNCTION: [Isoform D1]: Inhibits UV-damaged DNA repair. .; FUNCTION: [Isoform D2]: Inhibits UV-damaged DNA repair. .

AccessionsENST00000378600.7 [Q92466-2]
A0A087X0X5
ENST00000622090.4
ENST00000378603.7 [Q92466-4]
Q92466
ENST00000256996.9 [Q92466-1]
A0A087WTQ7
A0A087WV56
ENST00000614825.4
A0A087WYT8
ENST00000378601.7 [Q92466-5]
A0A087WW71
ENST00000616278.4 [Q92466-3]
ENST00000617847.4
ENST00000610805.4
ENST00000622878.4