DCP1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031087Biological processdeadenylation-independent decapping of nuclear-transcribed mRNA
GO_1903608Biological processprotein localization to cytoplasmic stress granule
GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0000290Biological processdeadenylation-dependent decapping of nuclear-transcribed mRNA
GO_0110156Biological processmRNA methylguanosine-cap decapping
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0030425Cellular componentdendrite
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0005634Cellular componentnucleus
GO_0008047Molecular functionenzyme activator activity
GO_0140933Molecular function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0042802Molecular functionidentical protein binding
GO_0019894Molecular functionkinesin binding

IV. Literature review

[source]
Gene nameDCP1A
Protein name5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase (EC 3.6.1.62)
mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF)
SynonymsSMIF
DescriptionFUNCTION: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay . Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP . Contributes to the transactivation of target genes after stimulation by TGFB1 . Essential for embryonic development . .

AccessionsA0A0S2Z5I2
ENST00000559748.5
A0A087WXD0
ENST00000560076.2
A0A0S2Z5K3
ENST00000294241.10 [Q9NPI6-2]
A0A087WVE6
Q9NPI6
ENST00000610213.6 [Q9NPI6-1]
ENST00000560624.5
A0A0S2Z5R3
A0A087WT55