Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 14 studies | 23% ± 9% | |
| fibroblast | 10 studies | 20% ± 5% | |
| adipocyte | 8 studies | 23% ± 4% | |
| astrocyte | 6 studies | 26% ± 9% | |
| epithelial cell | 5 studies | 31% ± 16% | |
| endothelial cell of lymphatic vessel | 5 studies | 21% ± 6% | |
| oligodendrocyte | 5 studies | 22% ± 5% | |
| pericyte | 5 studies | 18% ± 4% | |
| macrophage | 5 studies | 22% ± 5% | |
| glutamatergic neuron | 4 studies | 40% ± 22% | |
| microglial cell | 4 studies | 23% ± 5% | |
| myeloid cell | 4 studies | 18% ± 3% | |
| cardiac muscle cell | 4 studies | 21% ± 2% | |
| GABAergic neuron | 4 studies | 32% ± 15% | |
| interneuron | 4 studies | 36% ± 20% | |
| B cell | 3 studies | 22% ± 6% | |
| CD4-positive, alpha-beta T cell | 3 studies | 21% ± 3% | |
| memory B cell | 3 studies | 16% ± 0% | |
| naive B cell | 3 studies | 16% ± 0% | |
| lymphocyte | 3 studies | 20% ± 2% | |
| type II pneumocyte | 3 studies | 19% ± 3% | |
| oligodendrocyte precursor cell | 3 studies | 30% ± 10% | |
| CD8-positive, alpha-beta T cell | 3 studies | 18% ± 4% | |
| dendritic cell | 3 studies | 28% ± 12% | |
| abnormal cell | 3 studies | 26% ± 10% | |
| club cell | 3 studies | 21% ± 4% | |
| myofibroblast cell | 3 studies | 20% ± 6% | |
| alveolar macrophage | 3 studies | 20% ± 6% | |
| smooth muscle cell | 3 studies | 17% ± 2% | |
| goblet cell | 3 studies | 30% ± 18% | |
| transit amplifying cell | 3 studies | 28% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2124.44 | 1445 / 1445 | 100% | 27.51 | 183 / 183 |
| intestine | 100% | 2321.78 | 966 / 966 | 100% | 22.00 | 527 / 527 |
| ovary | 100% | 2859.87 | 180 / 180 | 100% | 24.78 | 430 / 430 |
| prostate | 100% | 2012.23 | 245 / 245 | 100% | 18.64 | 502 / 502 |
| lung | 100% | 2287.72 | 578 / 578 | 100% | 17.50 | 1154 / 1155 |
| thymus | 100% | 2182.85 | 653 / 653 | 100% | 16.85 | 604 / 605 |
| breast | 100% | 2530.36 | 459 / 459 | 100% | 21.28 | 1116 / 1118 |
| bladder | 100% | 2373.00 | 21 / 21 | 100% | 16.53 | 503 / 504 |
| stomach | 100% | 1628.94 | 359 / 359 | 100% | 23.87 | 285 / 286 |
| uterus | 100% | 2791.77 | 170 / 170 | 100% | 15.53 | 457 / 459 |
| pancreas | 100% | 1046.87 | 327 / 328 | 99% | 16.96 | 177 / 178 |
| brain | 99% | 1297.70 | 2617 / 2642 | 100% | 17.86 | 705 / 705 |
| kidney | 100% | 1400.52 | 89 / 89 | 99% | 14.71 | 890 / 901 |
| skin | 100% | 2017.32 | 1809 / 1809 | 98% | 19.95 | 461 / 472 |
| adrenal gland | 100% | 2083.36 | 258 / 258 | 94% | 9.27 | 216 / 230 |
| liver | 100% | 955.89 | 226 / 226 | 90% | 6.98 | 364 / 406 |
| adipose | 100% | 2651.78 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2224.73 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 16.67 | 29 / 29 |
| muscle | 100% | 1598.03 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2117.77 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 15.10 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 5.75 | 1 / 1 |
| heart | 99% | 1463.85 | 852 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 91% | 1395.96 | 846 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 80% | 6.99 | 64 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0031087 | Biological process | deadenylation-independent decapping of nuclear-transcribed mRNA |
| GO_1903608 | Biological process | protein localization to cytoplasmic stress granule |
| GO_0000184 | Biological process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| GO_0000290 | Biological process | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| GO_0110156 | Biological process | mRNA methylguanosine-cap decapping |
| GO_0000932 | Cellular component | P-body |
| GO_0005829 | Cellular component | cytosol |
| GO_0030425 | Cellular component | dendrite |
| GO_0016020 | Cellular component | membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0036464 | Cellular component | cytoplasmic ribonucleoprotein granule |
| GO_0005634 | Cellular component | nucleus |
| GO_0008047 | Molecular function | enzyme activator activity |
| GO_0140933 | Molecular function | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0003729 | Molecular function | mRNA binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0019894 | Molecular function | kinesin binding |
| Gene name | DCP1A |
| Protein name | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase (EC 3.6.1.62) mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) |
| Synonyms | SMIF |
| Description | FUNCTION: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay . Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP . Contributes to the transactivation of target genes after stimulation by TGFB1 . Essential for embryonic development . . |
| Accessions | A0A0S2Z5I2 ENST00000559748.5 A0A087WXD0 ENST00000560076.2 A0A0S2Z5K3 ENST00000294241.10 [Q9NPI6-2] A0A087WVE6 Q9NPI6 ENST00000610213.6 [Q9NPI6-1] ENST00000560624.5 A0A0S2Z5R3 A0A087WT55 |