Name | Number of supported studies | Average coverage | |
---|---|---|---|
basal cell | 7 studies | 23% ± 8% | |
endothelial cell | 6 studies | 23% ± 5% | |
epithelial cell | 5 studies | 35% ± 13% | |
fibroblast | 5 studies | 21% ± 5% | |
B cell | 4 studies | 19% ± 4% | |
natural killer cell | 4 studies | 18% ± 1% | |
conventional dendritic cell | 3 studies | 22% ± 5% | |
connective tissue cell | 3 studies | 19% ± 1% | |
ciliated cell | 3 studies | 26% ± 2% | |
CD8-positive, alpha-beta T cell | 3 studies | 19% ± 1% | |
endothelial cell of lymphatic vessel | 3 studies | 22% ± 2% | |
endothelial cell of vascular tree | 3 studies | 18% ± 2% | |
pericyte | 3 studies | 18% ± 3% | |
erythroblast | 3 studies | 23% ± 5% | |
dendritic cell | 3 studies | 28% ± 5% | |
intestinal crypt stem cell | 3 studies | 19% ± 3% | |
goblet cell | 3 studies | 18% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 1179.03 | 180 / 180 | 100% | 19.75 | 430 / 430 |
uterus | 100% | 1336.76 | 170 / 170 | 100% | 22.72 | 459 / 459 |
esophagus | 100% | 1265.94 | 1444 / 1445 | 100% | 20.90 | 183 / 183 |
breast | 100% | 1468.52 | 459 / 459 | 100% | 28.98 | 1117 / 1118 |
bladder | 100% | 1517.86 | 21 / 21 | 100% | 24.58 | 503 / 504 |
stomach | 100% | 1082.20 | 359 / 359 | 100% | 23.30 | 285 / 286 |
intestine | 100% | 1233.37 | 966 / 966 | 99% | 23.66 | 524 / 527 |
prostate | 100% | 1118.89 | 245 / 245 | 99% | 15.40 | 499 / 502 |
lung | 99% | 1159.40 | 574 / 578 | 100% | 22.53 | 1155 / 1155 |
pancreas | 100% | 962.36 | 328 / 328 | 99% | 14.13 | 176 / 178 |
thymus | 100% | 1205.60 | 653 / 653 | 99% | 11.27 | 598 / 605 |
brain | 99% | 748.19 | 2618 / 2642 | 100% | 15.52 | 702 / 705 |
skin | 100% | 2148.22 | 1809 / 1809 | 97% | 23.52 | 459 / 472 |
kidney | 100% | 1317.53 | 89 / 89 | 96% | 9.88 | 864 / 901 |
liver | 100% | 865.95 | 225 / 226 | 95% | 11.83 | 385 / 406 |
adrenal gland | 100% | 1594.55 | 258 / 258 | 92% | 9.61 | 211 / 230 |
adipose | 100% | 1524.49 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 23.14 | 29 / 29 |
spleen | 100% | 1459.98 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 18.24 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 12.93 | 1 / 1 |
blood vessel | 100% | 1187.71 | 1331 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 1001.91 | 799 / 803 | 0% | 0 | 0 / 0 |
heart | 97% | 883.58 | 833 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 89% | 14.74 | 71 / 80 |
peripheral blood | 65% | 1095.48 | 605 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016567 | Biological process | protein ubiquitination |
GO_0046697 | Biological process | decidualization |
GO_0001555 | Biological process | oocyte growth |
GO_0007056 | Biological process | spindle assembly involved in female meiosis |
GO_0000462 | Biological process | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
GO_0006364 | Biological process | rRNA processing |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0044725 | Biological process | epigenetic programming in the zygotic pronuclei |
GO_0005730 | Cellular component | nucleolus |
GO_0032040 | Cellular component | small-subunit processome |
GO_0005813 | Cellular component | centrosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0080008 | Cellular component | Cul4-RING E3 ubiquitin ligase complex |
GO_0005829 | Cellular component | cytosol |
GO_0030054 | Cellular component | cell junction |
GO_1990756 | Molecular function | ubiquitin-like ligase-substrate adaptor activity |
GO_0030331 | Molecular function | nuclear estrogen receptor binding |
GO_0003723 | Molecular function | RNA binding |
GO_0005515 | Molecular function | protein binding |
Gene name | DCAF13 |
Protein name | DDB1 and CUL4 associated factor 13 (cDNA FLJ10831 fis, clone NT2RP4001148, highly similar to Homo sapiens WD repeats and SOF1 domain containing (WDSOF1), mRNA) DDB1 and CUL4 associated factor 13 DDB1- and CUL4-associated factor 13 (WD repeat and SOF domain-containing protein 1) |
Synonyms | WDSOF1 HSPC064 |
Description | FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome . Participates in the 18S rRNA processing in growing oocytes, being essential for oocyte nonsurrounded nucleolus (NSN) to surrounded nucleolus (SN) transition . .; FUNCTION: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex that plays a key role in embryo preimplantation and is required for normal meiotic cycle progression in oocytes . Acts as a maternal factor that regulates oocyte and zygotic chromatin tightness during maternal to zygotic transition (By similarity). Also involved in the transformation of the endometrium into the decidua, known as decidualization, providing a solid foundation for implantation of blastocysts . Recognizes the histone methyltransferases SUV39H1 and SUV39H2 and directs them to polyubiquitination and proteasomal degradation, which facilitates the H3K9me3 removal and early zygotic gene expression, essential steps for progressive genome reprogramming and the establishment of pluripotency during preimplantation embryonic development . Supports the spindle assembly and chromosome condensation during oocyte meiotic division by targeting the polyubiquitination and degradation of PTEN, a lipid phosphatase that inhibits PI3K pathway as well as oocyte growth and maturation . Targets PMP22 for polyubiquitination and proteasomal degradation (By similarity). . |
Accessions | B3KME9 A0A087WT20 Q9NV06 ENST00000612750.5 [Q9NV06-1] ENST00000297579.9 ENST00000616836.4 ENST00000519682.5 ENST00000521971.5 A0A087X1F8 E5RHM4 ENST00000521999.5 |