DCAF13 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0046697Biological processdecidualization
GO_0001555Biological processoocyte growth
GO_0007056Biological processspindle assembly involved in female meiosis
GO_0000462Biological processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO_0006364Biological processrRNA processing
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0044725Biological processepigenetic programming in the zygotic pronuclei
GO_0005730Cellular componentnucleolus
GO_0032040Cellular componentsmall-subunit processome
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0080008Cellular componentCul4-RING E3 ubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0030054Cellular componentcell junction
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0030331Molecular functionnuclear estrogen receptor binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDCAF13
Protein nameDDB1 and CUL4 associated factor 13 (cDNA FLJ10831 fis, clone NT2RP4001148, highly similar to Homo sapiens WD repeats and SOF1 domain containing (WDSOF1), mRNA)
DDB1 and CUL4 associated factor 13
DDB1- and CUL4-associated factor 13 (WD repeat and SOF domain-containing protein 1)
SynonymsWDSOF1
HSPC064
DescriptionFUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome . Participates in the 18S rRNA processing in growing oocytes, being essential for oocyte nonsurrounded nucleolus (NSN) to surrounded nucleolus (SN) transition . .; FUNCTION: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex that plays a key role in embryo preimplantation and is required for normal meiotic cycle progression in oocytes . Acts as a maternal factor that regulates oocyte and zygotic chromatin tightness during maternal to zygotic transition (By similarity). Also involved in the transformation of the endometrium into the decidua, known as decidualization, providing a solid foundation for implantation of blastocysts . Recognizes the histone methyltransferases SUV39H1 and SUV39H2 and directs them to polyubiquitination and proteasomal degradation, which facilitates the H3K9me3 removal and early zygotic gene expression, essential steps for progressive genome reprogramming and the establishment of pluripotency during preimplantation embryonic development . Supports the spindle assembly and chromosome condensation during oocyte meiotic division by targeting the polyubiquitination and degradation of PTEN, a lipid phosphatase that inhibits PI3K pathway as well as oocyte growth and maturation . Targets PMP22 for polyubiquitination and proteasomal degradation (By similarity). .

AccessionsB3KME9
A0A087WT20
Q9NV06
ENST00000612750.5 [Q9NV06-1]
ENST00000297579.9
ENST00000616836.4
ENST00000519682.5
ENST00000521971.5
A0A087X1F8
E5RHM4
ENST00000521999.5