DBF4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010571Biological processpositive regulation of nuclear cell cycle DNA replication
GO_0006260Biological processDNA replication
GO_1901987Biological processregulation of cell cycle phase transition
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0031431Cellular componentDbf4-dependent protein kinase complex
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0008047Molecular functionenzyme activator activity
GO_0003676Molecular functionnucleic acid binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameDBF4
Protein nameDBF4 zinc finger (cDNA FLJ59266, highly similar to Protein DBF4 homolog)
DBF4 zinc finger
DBF4 homolog (S. cerevisiae), isoform CRA_b (cDNA FLJ61644, highly similar to Protein DBF4 homolog)
Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1)
SynonymsZDBF1
ASK
hCG_2023664
DBF4A
DescriptionFUNCTION: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. .

AccessionsQ9UBU7
ENST00000265728.6 [Q9UBU7-1]
ENST00000413643.5 [Q9UBU7-2]
F8WF77
B7Z8C6
B4DXK0
ENST00000430279.5
ENST00000431138.5