Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| natural killer cell | 9 studies | 21% ± 5% | |
| CD8-positive, alpha-beta T cell | 9 studies | 19% ± 4% | |
| B cell | 7 studies | 20% ± 4% | |
| CD4-positive, alpha-beta T cell | 7 studies | 20% ± 4% | |
| regulatory T cell | 7 studies | 18% ± 3% | |
| CD16-positive, CD56-dim natural killer cell, human | 6 studies | 21% ± 6% | |
| CD8-positive, alpha-beta memory T cell | 6 studies | 20% ± 5% | |
| CD16-negative, CD56-bright natural killer cell, human | 5 studies | 20% ± 3% | |
| T cell | 4 studies | 17% ± 2% | |
| naive B cell | 4 studies | 20% ± 4% | |
| effector memory CD8-positive, alpha-beta T cell | 4 studies | 21% ± 7% | |
| epithelial cell | 4 studies | 24% ± 6% | |
| gamma-delta T cell | 4 studies | 26% ± 9% | |
| plasmablast | 3 studies | 39% ± 13% | |
| naive thymus-derived CD4-positive, alpha-beta T cell | 3 studies | 18% ± 3% | |
| hematopoietic precursor cell | 3 studies | 19% ± 4% | |
| glutamatergic neuron | 3 studies | 27% ± 4% | |
| transit amplifying cell | 3 studies | 23% ± 7% | |
| mature NK T cell | 3 studies | 17% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| peripheral blood | 3 studies | 20% ± 0% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 349.22 | 1443 / 1445 | 100% | 22.15 | 183 / 183 |
| ovary | 100% | 675.42 | 180 / 180 | 100% | 12.48 | 429 / 430 |
| breast | 100% | 400.59 | 459 / 459 | 99% | 12.81 | 1110 / 1118 |
| lung | 100% | 440.75 | 577 / 578 | 99% | 14.42 | 1142 / 1155 |
| uterus | 100% | 439.91 | 170 / 170 | 99% | 15.84 | 453 / 459 |
| stomach | 100% | 337.44 | 359 / 359 | 99% | 16.27 | 282 / 286 |
| intestine | 100% | 391.46 | 965 / 966 | 97% | 16.36 | 512 / 527 |
| bladder | 100% | 324.81 | 21 / 21 | 97% | 13.07 | 489 / 504 |
| prostate | 100% | 517.23 | 245 / 245 | 96% | 7.15 | 484 / 502 |
| pancreas | 99% | 239.02 | 324 / 328 | 93% | 6.68 | 166 / 178 |
| skin | 100% | 712.43 | 1807 / 1809 | 92% | 13.25 | 433 / 472 |
| brain | 96% | 254.27 | 2539 / 2642 | 93% | 9.55 | 654 / 705 |
| thymus | 100% | 341.14 | 652 / 653 | 74% | 4.69 | 450 / 605 |
| kidney | 100% | 269.83 | 89 / 89 | 62% | 3.48 | 562 / 901 |
| liver | 98% | 204.01 | 222 / 226 | 54% | 3.20 | 218 / 406 |
| adrenal gland | 100% | 332.76 | 258 / 258 | 50% | 3.05 | 116 / 230 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 19.71 | 29 / 29 |
| spleen | 100% | 749.21 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 16.99 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 4.00 | 1 / 1 |
| adipose | 100% | 382.48 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 98% | 212.80 | 1305 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 91% | 928.38 | 843 / 929 | 0% | 0 | 0 / 0 |
| muscle | 86% | 129.52 | 693 / 803 | 0% | 0 | 0 / 0 |
| heart | 85% | 125.62 | 731 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 35% | 1.93 | 28 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0010571 | Biological process | positive regulation of nuclear cell cycle DNA replication |
| GO_0006260 | Biological process | DNA replication |
| GO_1901987 | Biological process | regulation of cell cycle phase transition |
| GO_0000082 | Biological process | G1/S transition of mitotic cell cycle |
| GO_0031431 | Cellular component | Dbf4-dependent protein kinase complex |
| GO_0016604 | Cellular component | nuclear body |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0043539 | Molecular function | protein serine/threonine kinase activator activity |
| GO_0008047 | Molecular function | enzyme activator activity |
| GO_0003676 | Molecular function | nucleic acid binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0008270 | Molecular function | zinc ion binding |
| Gene name | DBF4 |
| Protein name | DBF4 zinc finger (cDNA FLJ59266, highly similar to Protein DBF4 homolog) DBF4 zinc finger DBF4 homolog (S. cerevisiae), isoform CRA_b (cDNA FLJ61644, highly similar to Protein DBF4 homolog) Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) |
| Synonyms | ZDBF1 ASK hCG_2023664 DBF4A |
| Description | FUNCTION: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. . |
| Accessions | Q9UBU7 ENST00000265728.6 [Q9UBU7-1] ENST00000413643.5 [Q9UBU7-2] F8WF77 B7Z8C6 B4DXK0 ENST00000430279.5 ENST00000431138.5 |