CYB5R4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030073Biological processinsulin secretion
GO_0006801Biological processsuperoxide metabolic process
GO_0015701Biological processbicarbonate transport
GO_0048468Biological processcell development
GO_0046677Biological processresponse to antibiotic
GO_0042593Biological processglucose homeostasis
GO_0003032Biological processdetection of oxygen
GO_0072593Biological processreactive oxygen species metabolic process
GO_0005737Cellular componentcytoplasm
GO_0005783Cellular componentendoplasmic reticulum
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0016653Molecular functionoxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
GO_0004128Molecular functioncytochrome-b5 reductase activity, acting on NAD(P)H
GO_0016174Molecular functionNAD(P)H oxidase H2O2-forming activity
GO_0020037Molecular functionheme binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameCYB5R4
Protein nameCytochrome b5 reductase 4 (EC 1.6.2.2) (Flavohemoprotein b5/b5R) (b5+b5R) (N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein) (cb5/cb5R)
Cytochrome b5 reductase 4
SynonymsNCB5OR
DescriptionFUNCTION: NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.

AccessionsENST00000369681.10
ENST00000369679.4
Q7L1T6
A0A0A0MRM6