Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| classical monocyte | 13 studies | 23% ± 8% | |
| macrophage | 11 studies | 27% ± 10% | |
| non-classical monocyte | 10 studies | 24% ± 9% | |
| oligodendrocyte | 9 studies | 29% ± 10% | |
| B cell | 8 studies | 22% ± 4% | |
| microglial cell | 8 studies | 27% ± 10% | |
| monocyte | 8 studies | 24% ± 6% | |
| oligodendrocyte precursor cell | 6 studies | 28% ± 12% | |
| GABAergic neuron | 6 studies | 36% ± 19% | |
| endothelial cell | 5 studies | 22% ± 8% | |
| myeloid cell | 5 studies | 28% ± 9% | |
| dendritic cell | 5 studies | 29% ± 15% | |
| astrocyte | 5 studies | 32% ± 12% | |
| conventional dendritic cell | 4 studies | 32% ± 15% | |
| mononuclear phagocyte | 4 studies | 24% ± 8% | |
| glutamatergic neuron | 4 studies | 50% ± 20% | |
| interneuron | 4 studies | 41% ± 24% | |
| precursor B cell | 3 studies | 26% ± 3% | |
| neutrophil | 3 studies | 20% ± 3% | |
| epithelial cell | 3 studies | 29% ± 5% | |
| immature B cell | 3 studies | 20% ± 3% | |
| endothelial cell of lymphatic vessel | 3 studies | 18% ± 2% | |
| mast cell | 3 studies | 21% ± 4% | |
| naive B cell | 3 studies | 20% ± 4% | |
| plasmacytoid dendritic cell | 3 studies | 21% ± 5% | |
| memory B cell | 3 studies | 16% ± 0% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1034.80 | 1445 / 1445 | 100% | 8.75 | 183 / 183 |
| lung | 100% | 1402.92 | 578 / 578 | 100% | 9.00 | 1152 / 1155 |
| bladder | 100% | 1215.71 | 21 / 21 | 98% | 8.19 | 495 / 504 |
| breast | 100% | 1078.94 | 459 / 459 | 98% | 7.54 | 1093 / 1118 |
| intestine | 100% | 1219.92 | 966 / 966 | 97% | 8.85 | 512 / 527 |
| brain | 98% | 869.87 | 2592 / 2642 | 99% | 6.38 | 698 / 705 |
| stomach | 100% | 805.91 | 359 / 359 | 97% | 8.51 | 277 / 286 |
| uterus | 100% | 903.81 | 170 / 170 | 97% | 7.13 | 443 / 459 |
| kidney | 100% | 798.85 | 89 / 89 | 94% | 6.03 | 848 / 901 |
| pancreas | 95% | 436.00 | 311 / 328 | 99% | 6.21 | 176 / 178 |
| thymus | 100% | 764.33 | 652 / 653 | 91% | 3.98 | 551 / 605 |
| prostate | 100% | 888.15 | 245 / 245 | 89% | 4.13 | 449 / 502 |
| adrenal gland | 100% | 809.35 | 257 / 258 | 87% | 5.06 | 199 / 230 |
| skin | 100% | 982.92 | 1806 / 1809 | 86% | 5.11 | 404 / 472 |
| ovary | 100% | 698.47 | 180 / 180 | 80% | 3.00 | 342 / 430 |
| liver | 99% | 456.22 | 223 / 226 | 71% | 2.91 | 290 / 406 |
| adipose | 100% | 1207.42 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 10.73 | 29 / 29 |
| spleen | 100% | 2059.80 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.56 | 1 / 1 |
| blood vessel | 100% | 1219.99 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 100% | 4237.13 | 927 / 929 | 0% | 0 | 0 / 0 |
| muscle | 100% | 913.75 | 800 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 9.46 | 44 / 45 |
| heart | 95% | 648.70 | 817 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 49% | 1.62 | 39 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0030073 | Biological process | insulin secretion |
| GO_0006801 | Biological process | superoxide metabolic process |
| GO_0015701 | Biological process | bicarbonate transport |
| GO_0048468 | Biological process | cell development |
| GO_0046677 | Biological process | response to antibiotic |
| GO_0042593 | Biological process | glucose homeostasis |
| GO_0003032 | Biological process | detection of oxygen |
| GO_0072593 | Biological process | reactive oxygen species metabolic process |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0016653 | Molecular function | oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor |
| GO_0004128 | Molecular function | cytochrome-b5 reductase activity, acting on NAD(P)H |
| GO_0016174 | Molecular function | NAD(P)H oxidase H2O2-forming activity |
| GO_0020037 | Molecular function | heme binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | CYB5R4 |
| Protein name | Cytochrome b5 reductase 4 (EC 1.6.2.2) (Flavohemoprotein b5/b5R) (b5+b5R) (N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein) (cb5/cb5R) Cytochrome b5 reductase 4 |
| Synonyms | NCB5OR |
| Description | FUNCTION: NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin. |
| Accessions | ENST00000369681.10 ENST00000369679.4 Q7L1T6 A0A0A0MRM6 |