CTDSPL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000134Biological processnegative regulation of G1/S transition of mitotic cell cycle
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0008150Biological processbiological_process
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0070062Cellular componentextracellular exosome
GO_0005634Cellular componentnucleus
GO_0008420Molecular functionRNA polymerase II CTD heptapeptide repeat phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0017018Molecular functionmyosin phosphatase activity
GO_0046872Molecular functionmetal ion binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameCTDSPL
Protein nameprotein-serine/threonine phosphatase (EC 3.1.3.16)
CTD small phosphatase-like protein (CTDSP-like) (EC 3.1.3.16) (Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3) (NIF-like protein) (Nuclear LIM interactor-interacting factor 1) (NLI-interacting factor 1) (Protein YA22) (hYA22) (RBSP3) (Small C-terminal domain phosphatase 3) (SCP3) (Small CTD phosphatase 3)
CTD small phosphatase like
SynonymsC3orf8
NIF1
SCP3
YA22
NIFL
DescriptionFUNCTION: Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. .

AccessionsO15194
ENST00000436654.2
ENST00000435525.1
ENST00000447745.5
ENST00000443503.6 [O15194-2]
H7C353
H7C2B9
ENST00000273179.10 [O15194-1]
F8WED2
H7C2S4
ENST00000416688.6