Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 17 studies | 42% ± 20% | |
pericyte | 15 studies | 26% ± 11% | |
endothelial cell | 14 studies | 31% ± 16% | |
glutamatergic neuron | 13 studies | 43% ± 25% | |
fibroblast | 12 studies | 28% ± 11% | |
smooth muscle cell | 10 studies | 28% ± 7% | |
oligodendrocyte precursor cell | 10 studies | 31% ± 11% | |
type I pneumocyte | 9 studies | 27% ± 10% | |
endothelial cell of lymphatic vessel | 8 studies | 33% ± 12% | |
macrophage | 8 studies | 24% ± 7% | |
epithelial cell | 8 studies | 32% ± 13% | |
basal cell | 8 studies | 40% ± 22% | |
GABAergic neuron | 7 studies | 51% ± 22% | |
club cell | 6 studies | 25% ± 10% | |
platelet | 5 studies | 30% ± 12% | |
neuron | 5 studies | 34% ± 14% | |
granule cell | 4 studies | 34% ± 7% | |
adipocyte | 4 studies | 27% ± 7% | |
type II pneumocyte | 4 studies | 23% ± 7% | |
interneuron | 4 studies | 50% ± 21% | |
GABAergic interneuron | 3 studies | 32% ± 2% | |
glial cell | 3 studies | 25% ± 6% | |
cardiac muscle cell | 3 studies | 17% ± 1% | |
ependymal cell | 3 studies | 38% ± 22% | |
connective tissue cell | 3 studies | 18% ± 3% | |
megakaryocyte | 3 studies | 46% ± 8% | |
enteroendocrine cell | 3 studies | 27% ± 16% | |
intestinal crypt stem cell | 3 studies | 24% ± 7% | |
myofibroblast cell | 3 studies | 33% ± 8% | |
ciliated cell | 3 studies | 28% ± 6% | |
transit amplifying cell | 3 studies | 47% ± 33% | |
oligodendrocyte | 3 studies | 28% ± 8% | |
kidney distal convoluted tubule epithelial cell | 3 studies | 36% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 3160.56 | 180 / 180 | 100% | 34.87 | 430 / 430 |
prostate | 100% | 5310.90 | 245 / 245 | 100% | 48.58 | 502 / 502 |
intestine | 100% | 5386.26 | 966 / 966 | 99% | 42.19 | 524 / 527 |
breast | 100% | 3759.42 | 459 / 459 | 99% | 39.27 | 1111 / 1118 |
kidney | 100% | 6247.34 | 89 / 89 | 99% | 42.68 | 895 / 901 |
stomach | 100% | 4351.02 | 359 / 359 | 99% | 44.95 | 283 / 286 |
esophagus | 100% | 4260.16 | 1445 / 1445 | 99% | 38.41 | 181 / 183 |
lung | 100% | 4935.46 | 578 / 578 | 99% | 31.35 | 1142 / 1155 |
bladder | 100% | 4821.81 | 21 / 21 | 99% | 33.08 | 498 / 504 |
uterus | 100% | 3539.35 | 170 / 170 | 99% | 33.09 | 453 / 459 |
skin | 100% | 6020.11 | 1809 / 1809 | 97% | 52.63 | 460 / 472 |
brain | 97% | 2354.04 | 2562 / 2642 | 98% | 20.43 | 690 / 705 |
thymus | 100% | 2818.27 | 652 / 653 | 92% | 19.08 | 559 / 605 |
pancreas | 92% | 1455.24 | 302 / 328 | 99% | 45.62 | 177 / 178 |
liver | 95% | 1646.06 | 215 / 226 | 90% | 22.05 | 367 / 406 |
adrenal gland | 97% | 1533.89 | 249 / 258 | 82% | 13.68 | 188 / 230 |
adipose | 100% | 3260.46 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 6262.53 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 32.24 | 80 / 80 |
spleen | 100% | 3293.96 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 31.97 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 9.48 | 1 / 1 |
heart | 98% | 2620.63 | 842 / 861 | 0% | 0 | 0 / 0 |
muscle | 89% | 1679.71 | 717 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 9% | 92.20 | 85 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 7% | 0.75 | 2 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_2000134 | Biological process | negative regulation of G1/S transition of mitotic cell cycle |
GO_0001933 | Biological process | negative regulation of protein phosphorylation |
GO_0008150 | Biological process | biological_process |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005634 | Cellular component | nucleus |
GO_0008420 | Molecular function | RNA polymerase II CTD heptapeptide repeat phosphatase activity |
GO_0005515 | Molecular function | protein binding |
GO_0017018 | Molecular function | myosin phosphatase activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0003674 | Molecular function | molecular_function |
Gene name | CTDSPL |
Protein name | protein-serine/threonine phosphatase (EC 3.1.3.16) CTD small phosphatase-like protein (CTDSP-like) (EC 3.1.3.16) (Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3) (NIF-like protein) (Nuclear LIM interactor-interacting factor 1) (NLI-interacting factor 1) (Protein YA22) (hYA22) (RBSP3) (Small C-terminal domain phosphatase 3) (SCP3) (Small CTD phosphatase 3) CTD small phosphatase like |
Synonyms | C3orf8 NIF1 SCP3 YA22 NIFL |
Description | FUNCTION: Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. . |
Accessions | O15194 ENST00000436654.2 ENST00000435525.1 ENST00000447745.5 ENST00000443503.6 [O15194-2] H7C353 H7C2B9 ENST00000273179.10 [O15194-1] F8WED2 H7C2S4 ENST00000416688.6 |