CTCFL report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CTCFL at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CTCFL at tissue level.

III. Associated gene sets

GO_0071169Biological processestablishment of protein localization to chromatin
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010628Biological processpositive regulation of gene expression
GO_0071514Biological processgenomic imprinting
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005694Cellular componentchromosome
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0042393Molecular functionhistone binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0046872Molecular functionmetal ion binding
GO_0043035Molecular functionchromatin insulator sequence binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCTCFL
Protein nameTranscriptional repressor CTCFL (Brother of the regulator of imprinted sites) (CCCTC-binding factor) (CTCF paralog) (CTCF-like protein) (Cancer/testis antigen 27) (CT27) (Zinc finger protein CTCF-T)
CCCTC-binding factor like
SynonymsBORIS
DescriptionFUNCTION: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. .

AccessionsQ8NI51
V9GY73
ENST00000539382.5 [Q8NI51-5]
V9GZ46
ENST00000481655.2
ENST00000423479.7 [Q8NI51-7]
ENST00000608158.5
V9GYX4
ENST00000608425.5
F5H2V8
ENST00000608903.5 [Q8NI51-11]
ENST00000422109.6 [Q8NI51-9]
ENST00000371196.6 [Q8NI51-1]
ENST00000432255.6 [Q8NI51-4]
ENST00000243914.8 [Q8NI51-1]
ENST00000608440.5 [Q8NI51-3]
ENST00000422869.6 [Q8NI51-2]
ENST00000609232.5 [Q8NI51-1]
ENST00000608263.5 [Q8NI51-1]
ENST00000433949.7 [Q8NI51-10]
ENST00000426658.6
ENST00000429804.7 [Q8NI51-8]
ENST00000502686.6 [Q8NI51-6]
ENST00000608720.5