CREB3L3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CREB3L3 at tissue level.

III. Associated gene sets

GO_0006986Biological processresponse to unfolded protein
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0002675Biological processpositive regulation of acute inflammatory response
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005654Cellular componentnucleoplasm
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0042802Molecular functionidentical protein binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCREB3L3
Protein nameCyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3]
SynonymsHYST1481
CREBH
DescriptionFUNCTION: Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription (By similarity). Plays a crucial role in the regulation of triglyceride metabolism and is required for the maintenance of normal plasma triglyceride concentrations . .

AccessionsENST00000602147.1 [Q68CJ9-5]
ENST00000078445.7 [Q68CJ9-1]
Q68CJ9
ENST00000595923.5 [Q68CJ9-2]
ENST00000602257.5 [Q68CJ9-4]