CPSF7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051262Biological processprotein tetramerization
GO_0031124Biological processmRNA 3'-end processing
GO_0110104Biological processmRNA alternative polyadenylation
GO_0180010Biological processco-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway
GO_0051290Biological processprotein heterotetramerization
GO_0005847Cellular componentmRNA cleavage and polyadenylation specificity factor complex
GO_0005849Cellular componentmRNA cleavage factor complex
GO_0005654Cellular componentnucleoplasm
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameCPSF7
Protein nameCleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit)
Cleavage and polyadenylation specific factor 7
Synonyms
DescriptionFUNCTION: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs . CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) . Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation . The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs . CPSF7 activates directly the mRNA 3'-processing machinery . Binds to pA signals in RNA substrates . .

AccessionsENST00000448745.5 [Q8N684-2]
ENST00000413184.6
ENST00000544990.5
F5H5B7
ENST00000543545.5
ENST00000544585.5
F5H047
ENST00000536548.5
F5GXA3
F5H669
J3QT54
C9JM38
F5H2K8
ENST00000626926.1
ENST00000477890.6
C9J286
ENST00000450000.5
ENST00000413232.5
F5H6A8
ENST00000541963.5
F5H6P5
ENST00000394888.8 [Q8N684-1]
C9J323
ENST00000449811.5
ENST00000535222.5
ENST00000340437.8 [Q8N684-3]
ENST00000439958.8 [Q8N684-2]
F5H1W4
Q8N684
ENST00000537162.5
F5H6M0
ENST00000536145.3
ENST00000539952.5