Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 8 studies | 24% ± 6% | |
astrocyte | 7 studies | 31% ± 13% | |
epithelial cell | 4 studies | 31% ± 6% | |
oligodendrocyte precursor cell | 4 studies | 29% ± 4% | |
macrophage | 4 studies | 20% ± 2% | |
naive B cell | 4 studies | 17% ± 2% | |
oligodendrocyte | 4 studies | 20% ± 4% | |
classical monocyte | 3 studies | 22% ± 5% | |
microglial cell | 3 studies | 21% ± 2% | |
ciliated cell | 3 studies | 23% ± 4% | |
fibroblast | 3 studies | 17% ± 1% | |
GABAergic neuron | 3 studies | 39% ± 5% | |
glutamatergic neuron | 3 studies | 48% ± 8% | |
abnormal cell | 3 studies | 24% ± 4% | |
transit amplifying cell | 3 studies | 24% ± 8% | |
neuron | 3 studies | 23% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 7625.24 | 1445 / 1445 | 100% | 53.96 | 183 / 183 |
intestine | 100% | 8171.85 | 966 / 966 | 100% | 42.57 | 527 / 527 |
lung | 100% | 6930.96 | 578 / 578 | 100% | 52.42 | 1155 / 1155 |
prostate | 100% | 8904.04 | 245 / 245 | 100% | 57.78 | 502 / 502 |
skin | 100% | 7942.46 | 1809 / 1809 | 100% | 49.72 | 472 / 472 |
stomach | 100% | 6716.38 | 359 / 359 | 100% | 42.51 | 286 / 286 |
thymus | 100% | 11477.19 | 653 / 653 | 100% | 58.02 | 605 / 605 |
uterus | 100% | 10751.09 | 170 / 170 | 100% | 57.55 | 459 / 459 |
ovary | 100% | 9409.48 | 180 / 180 | 100% | 57.88 | 429 / 430 |
brain | 100% | 5536.16 | 2635 / 2642 | 100% | 76.08 | 705 / 705 |
breast | 100% | 8175.69 | 459 / 459 | 100% | 58.58 | 1114 / 1118 |
bladder | 100% | 8241.52 | 21 / 21 | 100% | 48.57 | 502 / 504 |
pancreas | 100% | 4936.50 | 328 / 328 | 99% | 42.50 | 177 / 178 |
kidney | 100% | 7009.08 | 89 / 89 | 99% | 43.04 | 893 / 901 |
liver | 100% | 5659.36 | 226 / 226 | 97% | 29.58 | 395 / 406 |
adrenal gland | 100% | 7442.23 | 258 / 258 | 96% | 36.23 | 221 / 230 |
adipose | 100% | 7533.70 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 8196.05 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 41.06 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 49.29 | 29 / 29 |
muscle | 100% | 6472.73 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 10137.00 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 55.24 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 28.69 | 1 / 1 |
heart | 99% | 3975.51 | 855 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 97% | 5816.60 | 900 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0051262 | Biological process | protein tetramerization |
GO_0031124 | Biological process | mRNA 3'-end processing |
GO_0110104 | Biological process | mRNA alternative polyadenylation |
GO_0180010 | Biological process | co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway |
GO_0051290 | Biological process | protein heterotetramerization |
GO_0005847 | Cellular component | mRNA cleavage and polyadenylation specificity factor complex |
GO_0005849 | Cellular component | mRNA cleavage factor complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0016020 | Cellular component | membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005515 | Molecular function | protein binding |
GO_0003729 | Molecular function | mRNA binding |
GO_0003723 | Molecular function | RNA binding |
Gene name | CPSF7 |
Protein name | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) Cleavage and polyadenylation specific factor 7 |
Synonyms | |
Description | FUNCTION: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs . CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) . Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation . The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs . CPSF7 activates directly the mRNA 3'-processing machinery . Binds to pA signals in RNA substrates . . |
Accessions | ENST00000448745.5 [Q8N684-2] ENST00000413184.6 ENST00000544990.5 F5H5B7 ENST00000543545.5 ENST00000544585.5 F5H047 ENST00000536548.5 F5GXA3 F5H669 J3QT54 C9JM38 F5H2K8 ENST00000626926.1 ENST00000477890.6 C9J286 ENST00000450000.5 ENST00000413232.5 F5H6A8 ENST00000541963.5 F5H6P5 ENST00000394888.8 [Q8N684-1] C9J323 ENST00000449811.5 ENST00000535222.5 ENST00000340437.8 [Q8N684-3] ENST00000439958.8 [Q8N684-2] F5H1W4 Q8N684 ENST00000537162.5 F5H6M0 ENST00000536145.3 ENST00000539952.5 |