CPQ | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	34 studies	33% ± 13%	Explore
endothelial cell	23 studies	30% ± 13%	Explore
pericyte	19 studies	24% ± 6%	Explore
astrocyte	17 studies	41% ± 22%	Explore
macrophage	17 studies	35% ± 17%	Explore
oligodendrocyte	15 studies	47% ± 19%	Explore
smooth muscle cell	15 studies	29% ± 9%	Explore
microglial cell	14 studies	40% ± 14%	Explore
connective tissue cell	12 studies	25% ± 10%	Explore
myofibroblast cell	10 studies	26% ± 8%	Explore
myeloid cell	9 studies	35% ± 14%	Explore
adipocyte	8 studies	33% ± 7%	Explore
mast cell	8 studies	22% ± 6%	Explore
monocyte	7 studies	33% ± 14%	Explore
oligodendrocyte precursor cell	6 studies	23% ± 9%	Explore
dendritic cell	6 studies	34% ± 6%	Explore
non-classical monocyte	5 studies	26% ± 7%	Explore
GABAergic neuron	5 studies	42% ± 19%	Explore
glutamatergic neuron	5 studies	42% ± 22%	Explore
cardiac muscle cell	5 studies	26% ± 4%	Explore
endothelial cell of lymphatic vessel	5 studies	28% ± 4%	Explore
classical monocyte	4 studies	24% ± 5%	Explore
conventional dendritic cell	4 studies	27% ± 6%	Explore
epithelial cell	4 studies	25% ± 11%	Explore
mesothelial cell	4 studies	27% ± 8%	Explore
lymphocyte	4 studies	24% ± 7%	Explore
retinal cone cell	4 studies	35% ± 12%	Explore
endothelial cell of vascular tree	4 studies	25% ± 9%	Explore
T cell	4 studies	20% ± 4%	Explore
natural killer cell	4 studies	22% ± 7%	Explore
kidney loop of Henle epithelial cell	4 studies	27% ± 5%	Explore
renal alpha-intercalated cell	4 studies	34% ± 9%	Explore
glomerular endothelial cell	3 studies	21% ± 3%	Explore
renal beta-intercalated cell	3 studies	32% ± 14%	Explore
glial cell	3 studies	25% ± 4%	Explore
retinal pigment epithelial cell	3 studies	38% ± 18%	Explore
mononuclear phagocyte	3 studies	35% ± 8%	Explore
Mueller cell	3 studies	25% ± 4%	Explore
hepatocyte	3 studies	50% ± 15%	Explore
muscle cell	3 studies	31% ± 10%	Explore
ependymal cell	3 studies	44% ± 25%	Explore
adventitial cell	3 studies	32% ± 11%	Explore
alveolar macrophage	3 studies	38% ± 11%	Explore
capillary endothelial cell	3 studies	22% ± 3%	Explore
type I pneumocyte	3 studies	22% ± 2%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	20% ± 5%	Explore
Schwann cell	3 studies	30% ± 16%	Explore
melanocyte	3 studies	39% ± 26%	Explore
interneuron	3 studies	53% ± 26%	Explore
myoepithelial cell	3 studies	26% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	27% ± 4%	Explore
renal principal cell	3 studies	23% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	12 studies	36% ± 21%	Explore
lung	6 studies	22% ± 5%	Explore
intestine	4 studies	20% ± 6%	Explore
heart	4 studies	28% ± 5%	Explore
adipose	4 studies	30% ± 9%	Explore
kidney	4 studies	27% ± 6%	Explore
eye	3 studies	28% ± 15%	Explore
liver	3 studies	34% ± 17%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	3294.30	89 / 89	99%	71.66	889 / 901
thymus	100%	12470.92	653 / 653	98%	176.27	592 / 605
breast	100%	3082.88	459 / 459	97%	48.75	1089 / 1118
prostate	100%	2579.86	244 / 245	97%	42.76	487 / 502
adrenal gland	97%	2023.45	251 / 258	97%	62.86	222 / 230
liver	93%	1350.50	211 / 226	100%	73.63	405 / 406
pancreas	95%	1231.85	311 / 328	95%	43.64	169 / 178
skin	98%	1983.73	1766 / 1809	89%	95.00	419 / 472
lung	99%	2798.65	575 / 578	85%	26.29	981 / 1155
ovary	100%	6134.68	180 / 180	81%	19.24	349 / 430
stomach	100%	2234.13	358 / 359	74%	19.10	213 / 286
bladder	100%	3187.00	21 / 21	72%	20.17	365 / 504
intestine	98%	2796.27	951 / 966	65%	16.42	341 / 527
uterus	99%	4323.39	169 / 170	60%	21.11	274 / 459
brain	83%	1150.08	2186 / 2642	68%	22.73	482 / 705
esophagus	80%	1940.64	1162 / 1445	55%	11.35	100 / 183
adipose	100%	3440.41	1204 / 1204	0%	0	0 / 0
blood vessel	100%	6184.13	1335 / 1335	0%	0	0 / 0
spleen	100%	2128.97	241 / 241	0%	0	0 / 0
heart	95%	2351.29	817 / 861	0%	0	0 / 0
peripheral blood	80%	3721.29	746 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	72%	15.02	21 / 29
eye	0%	0	0 / 0	55%	20.39	44 / 80
tonsil	0%	0	0 / 0	53%	10.03	24 / 45
muscle	24%	221.87	193 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006590	Biological process	thyroid hormone generation
GO_0042246	Biological process	tissue regeneration
GO_0006508	Biological process	proteolysis
GO_0043171	Biological process	peptide catabolic process
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005615	Cellular component	extracellular space
GO_0005764	Cellular component	lysosome
GO_0070062	Cellular component	extracellular exosome
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005794	Cellular component	Golgi apparatus
GO_0005737	Cellular component	cytoplasm
GO_0042803	Molecular function	protein homodimerization activity
GO_0070573	Molecular function	metallodipeptidase activity
GO_0004180	Molecular function	carboxypeptidase activity
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	CPQ
Protein name	Carboxypeptidase Q Carboxypeptidase Q (EC 3.4.17.-) (Lysosomal dipeptidase) (Plasma glutamate carboxypeptidase) Carboxypeptidase Q (Plasma glutamate carboxypeptidase)
Synonyms	PGCP LCH1
Description	FUNCTION: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor. FUNCTION: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor. .
Accessions	ENST00000517742.1 ENST00000220763.10 ENST00000521142.1 Q9Y646 E5RH35 ENST00000522617.3 H0YBB7 E5RJZ7 ENST00000519900.1 E5RJA8 E5RJP8 ENST00000519484.1

CPQ report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review