COA6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042774Biological processplasma membrane ATP synthesis coupled electron transport
GO_0042775Biological processmitochondrial ATP synthesis coupled electron transport
GO_0008535Biological processrespiratory chain complex IV assembly
GO_0045277Cellular componentrespiratory chain complex IV
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0005654Cellular componentnucleoplasm
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0003723Molecular functionRNA binding
GO_0005507Molecular functioncopper ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCOA6
Protein nameCytochrome c oxidase assembly factor 6 homolog
SynonymsC1orf31
DescriptionFUNCTION: Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV. .

AccessionsENST00000366613.1 [Q5JTJ3-1]
ENST00000366615.10 [Q5JTJ3-2]
Q5JTJ3
ENST00000366612.1 [Q5JTJ3-3]
ENST00000619305.1 [Q5JTJ3-3]