CLNK report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CLNK at tissue level.

III. Associated gene sets

GO_0043303Biological processmast cell degranulation
GO_0035556Biological processintracellular signal transduction
GO_0032815Biological processnegative regulation of natural killer cell activation
GO_0002729Biological processpositive regulation of natural killer cell cytokine production
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0042629Cellular componentmast cell granule
GO_0032991Cellular componentprotein-containing complex
GO_0005737Cellular componentcytoplasm
GO_0044877Molecular functionprotein-containing complex binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCLNK
Protein nameCytokine-dependent hematopoietic cell linker (Mast cell immunoreceptor signal transducer)
Cytokine dependent hematopoietic cell linker
SynonymsMIST
DescriptionFUNCTION: An adapter protein which plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation (By similarity). Together with FGR, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). Acts as a positive regulator of both T-cell receptor and natural killer T (NKT) cell receptor signaling in CD4-positive NKT cells (By similarity). Together with MAP4K1, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). May be involved in tumor necrosis factor induced cell death by promoting reactive oxidative species generation, and MLKL oligomerization, ultimately leading to necrosis (By similarity). Involved in phosphorylation of LAT (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity). .

AccessionsD6RJB9
Q7Z7G1
ENST00000515667.5
ENST00000226951.11 [Q7Z7G1-1]
ENST00000507719.1 [Q7Z7G1-2]