CLEC16A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901096Biological processregulation of autophagosome maturation
GO_0006914Biological processautophagy
GO_0016197Biological processendosomal transport
GO_1901097Biological processnegative regulation of autophagosome maturation
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0008333Biological processendosome to lysosome transport
GO_0009267Biological processcellular response to starvation
GO_0036020Cellular componentendolysosome membrane
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_0031982Cellular componentvesicle
GO_0005770Cellular componentlate endosome
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameCLEC16A
Protein nameC-type lectin domain containing 16A
Protein CLEC16A (C-type lectin domain family 16 member A)
C-type lectin domain containing 16A (KIAA0350 protein, isoform CRA_b)
SynonymshCG_1787643
KIAA0350
DescriptionFUNCTION: Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteasomal degradation, RNF41/NRDP1 which regulates proteasomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. .

AccessionsA0A8V8TR67
ENST00000409552.4 [Q2KHT3-2]
H7BZI2
ENST00000261657.5
H7BZJ9
ENST00000459723.1
ENST00000703130.1
ENST00000428742.6
A0A2R8YDG4
ENST00000436973.5
Q2KHT3
H7BXG1
ENST00000409790.6 [Q2KHT3-1]