CLDN1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
basal cell	18 studies	36% ± 18%	Explore
epithelial cell	8 studies	37% ± 17%	Explore
secretory cell	7 studies	38% ± 13%	Explore
ciliated cell	6 studies	30% ± 10%	Explore
mesothelial cell	6 studies	39% ± 10%	Explore
hepatocyte	5 studies	50% ± 25%	Explore
keratinocyte	4 studies	55% ± 20%	Explore
hillock cell	3 studies	36% ± 7%	Explore
squamous epithelial cell	3 studies	35% ± 24%	Explore
cholangiocyte	3 studies	38% ± 14%	Explore
club cell	3 studies	22% ± 9%	Explore
pancreatic ductal cell	3 studies	72% ± 12%	Explore
parietal epithelial cell	3 studies	37% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
skin	4 studies	23% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	11112.53	226 / 226	97%	276.37	393 / 406
pancreas	84%	3097.63	275 / 328	88%	169.47	156 / 178
uterus	84%	7777.42	142 / 170	73%	353.58	333 / 459
esophagus	39%	2253.24	563 / 1445	84%	256.57	154 / 183
adrenal gland	96%	7957.71	248 / 258	17%	24.22	40 / 230
bladder	33%	1913.10	7 / 21	78%	209.95	393 / 504
thymus	22%	648.91	144 / 653	82%	360.74	497 / 605
kidney	43%	1367.63	38 / 89	56%	100.35	505 / 901
lung	23%	677.85	134 / 578	73%	326.83	838 / 1155
tonsil	0%	0	0 / 0	96%	577.18	43 / 45
skin	72%	32045.15	1308 / 1809	21%	26.07	98 / 472
ovary	23%	730.94	42 / 180	68%	109.75	292 / 430
prostate	56%	2138.13	136 / 245	31%	23.09	156 / 502
intestine	0%	1.42	1 / 966	74%	88.87	391 / 527
stomach	0%	16.60	1 / 359	68%	88.63	194 / 286
breast	25%	714.38	116 / 459	18%	25.32	204 / 1118
adipose	37%	3240.89	448 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	3%	3.75	1 / 29
heart	3%	82.41	27 / 861	0%	0	0 / 0
blood vessel	3%	75.96	34 / 1335	0%	0	0 / 0
spleen	1%	18.87	2 / 241	0%	0	0 / 0
muscle	1%	14.93	5 / 803	0%	0	0 / 0
brain	0%	3.44	4 / 2642	0%	0.09	1 / 705
peripheral blood	0%	4.46	2 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0060054	Biological process	positive regulation of epithelial cell proliferation involved in wound healing
GO_0071560	Biological process	cellular response to transforming growth factor beta stimulus
GO_0061436	Biological process	establishment of skin barrier
GO_0070673	Biological process	response to interleukin-18
GO_0007155	Biological process	cell adhesion
GO_1903348	Biological process	positive regulation of bicellular tight junction assembly
GO_0045471	Biological process	response to ethanol
GO_0034331	Biological process	cell junction maintenance
GO_0008065	Biological process	establishment of blood-nerve barrier
GO_0045216	Biological process	cell-cell junction organization
GO_0016338	Biological process	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
GO_0071548	Biological process	response to dexamethasone
GO_0051259	Biological process	protein complex oligomerization
GO_0071356	Biological process	cellular response to tumor necrosis factor
GO_0046718	Biological process	symbiont entry into host cell
GO_1903545	Biological process	cellular response to butyrate
GO_0097421	Biological process	liver regeneration
GO_0030335	Biological process	positive regulation of cell migration
GO_0070830	Biological process	bicellular tight junction assembly
GO_0035633	Biological process	maintenance of blood-brain barrier
GO_0061772	Biological process	xenobiotic transport across blood-nerve barrier
GO_0090557	Biological process	establishment of endothelial intestinal barrier
GO_0009636	Biological process	response to toxic substance
GO_0032496	Biological process	response to lipopolysaccharide
GO_0071284	Biological process	cellular response to lead ion
GO_0071346	Biological process	cellular response to type II interferon
GO_0090303	Biological process	positive regulation of wound healing
GO_0016324	Cellular component	apical plasma membrane
GO_0070160	Cellular component	tight junction
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0032991	Cellular component	protein-containing complex
GO_0016328	Cellular component	lateral plasma membrane
GO_0005923	Cellular component	bicellular tight junction
GO_0016323	Cellular component	basolateral plasma membrane
GO_0042802	Molecular function	identical protein binding
GO_0001618	Molecular function	virus receptor activity
GO_0005198	Molecular function	structural molecule activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CLDN1
Protein name	Claudin Claudin-1 (Senescence-associated epithelial membrane protein)
Synonyms	CLD1 hCG_17574 SEMP1 UNQ481/PRO944
Description	FUNCTION: Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions . .; FUNCTION: (Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes . Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell . Acts as a receptor for dengue virus . . FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. .
Accessions	ENST00000295522.4 O95832 A5JSJ9

CLDN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review