I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 4 studies | 25% ± 8% | |
| dendritic cell | 3 studies | 21% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 4 studies | 25% ± 8% | |
| dendritic cell | 3 studies | 21% ± 5% |
Insufficient scRNA-seq data for expression of CIC at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 8133.37 | 1445 / 1445 | 100% | 62.64 | 183 / 183 |
| thymus | 100% | 10843.90 | 653 / 653 | 100% | 45.43 | 604 / 605 |
| uterus | 100% | 17090.52 | 170 / 170 | 100% | 44.29 | 457 / 459 |
| ovary | 100% | 13995.06 | 180 / 180 | 99% | 72.37 | 427 / 430 |
| brain | 100% | 10405.38 | 2630 / 2642 | 100% | 47.05 | 703 / 705 |
| skin | 100% | 8546.96 | 1809 / 1809 | 99% | 54.60 | 468 / 472 |
| breast | 100% | 10128.32 | 459 / 459 | 99% | 38.53 | 1108 / 1118 |
| intestine | 100% | 8346.68 | 966 / 966 | 99% | 28.62 | 521 / 527 |
| prostate | 100% | 9290.71 | 245 / 245 | 99% | 30.30 | 495 / 502 |
| stomach | 100% | 6504.58 | 359 / 359 | 99% | 34.92 | 282 / 286 |
| kidney | 100% | 7100.12 | 89 / 89 | 98% | 32.82 | 886 / 901 |
| bladder | 100% | 8450.76 | 21 / 21 | 98% | 30.12 | 495 / 504 |
| adrenal gland | 100% | 8240.29 | 258 / 258 | 98% | 42.41 | 225 / 230 |
| lung | 100% | 9291.79 | 577 / 578 | 98% | 36.98 | 1131 / 1155 |
| pancreas | 98% | 4491.72 | 321 / 328 | 99% | 31.86 | 176 / 178 |
| liver | 100% | 4418.76 | 225 / 226 | 94% | 20.16 | 381 / 406 |
| adipose | 100% | 8494.88 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 10737.85 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 61.93 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 30.05 | 29 / 29 |
| spleen | 100% | 9200.37 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 52.63 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 12.24 | 1 / 1 |
| muscle | 100% | 6067.51 | 802 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 7674.04 | 908 / 929 | 0% | 0 | 0 / 0 |
| heart | 98% | 4283.76 | 841 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007420 | Biological process | brain development |
| GO_0007613 | Biological process | memory |
| GO_0035176 | Biological process | social behavior |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0007612 | Biological process | learning |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CIC |
| Protein name | Protein capicua homolog Capicua transcriptional repressor |
| Synonyms | KIAA0306 |
| Description | FUNCTION: Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development. . |
| Accessions | ENST00000681038.1 ENST00000572681.6 I3L373 I3L2J0 ENST00000575287.1 ENST00000573349.5 ENST00000576505.6 Q96RK0 A0A7P0T9K5 I3L135 ENST00000160740.7 I3L1Q4 A0A0A0MQR4 ENST00000575354.6 |
