CHTOP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006406Biological processmRNA export from nucleus
GO_0051096Biological processpositive regulation of helicase activity
GO_0032781Biological processpositive regulation of ATP-dependent activity
GO_0006338Biological processchromatin remodeling
GO_0016607Cellular componentnuclear speck
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0000346Cellular componenttranscription export complex
GO_0005634Cellular componentnucleus
GO_0008327Molecular functionmethyl-CpG binding
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameCHTOP
Protein nameChromatin target of PRMT1
Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG)
SynonymsPP7704
HT031
C1orf77
FOP
DescriptionFUNCTION: Plays an important role in the ligand-dependent activation of estrogen receptor target genes . May play a role in the silencing of fetal globin genes . Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis . .; FUNCTION: Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity . .

AccessionsX6R700
Q9Y3Y2
A0A087X1B7
ENST00000614256.4
ENST00000368694.8 [Q9Y3Y2-1]
ENST00000368687.1
Q5T7Y7
ENST00000368686.1
ENST00000403433.5 [Q9Y3Y2-4]
ENST00000710369.1
A0AA34QVV3
ENST00000368690.7 [Q9Y3Y2-3]