Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 15 studies | 42% ± 20% | |
endothelial cell | 15 studies | 31% ± 13% | |
oligodendrocyte | 14 studies | 44% ± 17% | |
macrophage | 13 studies | 31% ± 15% | |
oligodendrocyte precursor cell | 12 studies | 36% ± 16% | |
microglial cell | 11 studies | 36% ± 11% | |
adipocyte | 9 studies | 34% ± 11% | |
epithelial cell | 8 studies | 30% ± 12% | |
mast cell | 8 studies | 22% ± 5% | |
type I pneumocyte | 8 studies | 30% ± 13% | |
myeloid cell | 7 studies | 31% ± 7% | |
GABAergic neuron | 6 studies | 39% ± 19% | |
glutamatergic neuron | 6 studies | 45% ± 25% | |
ciliated cell | 6 studies | 28% ± 11% | |
type II pneumocyte | 6 studies | 32% ± 11% | |
neuron | 5 studies | 35% ± 21% | |
dendritic cell | 5 studies | 22% ± 4% | |
club cell | 5 studies | 31% ± 13% | |
retina horizontal cell | 4 studies | 29% ± 8% | |
retinal pigment epithelial cell | 4 studies | 35% ± 11% | |
cardiac muscle cell | 4 studies | 22% ± 2% | |
respiratory goblet cell | 4 studies | 29% ± 13% | |
endothelial cell of lymphatic vessel | 4 studies | 29% ± 5% | |
interneuron | 4 studies | 36% ± 22% | |
mononuclear phagocyte | 3 studies | 19% ± 3% | |
Mueller cell | 3 studies | 22% ± 5% | |
retinal rod cell | 3 studies | 18% ± 2% | |
hepatocyte | 3 studies | 51% ± 24% | |
ependymal cell | 3 studies | 44% ± 10% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 23% ± 5% | |
monocyte | 3 studies | 26% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 2568.18 | 2642 / 2642 | 100% | 25.43 | 705 / 705 |
prostate | 100% | 2720.13 | 245 / 245 | 100% | 30.76 | 502 / 502 |
breast | 100% | 2218.46 | 459 / 459 | 100% | 21.88 | 1114 / 1118 |
stomach | 100% | 2803.05 | 359 / 359 | 98% | 19.66 | 281 / 286 |
thymus | 100% | 4409.35 | 653 / 653 | 98% | 20.42 | 594 / 605 |
intestine | 100% | 2021.00 | 966 / 966 | 98% | 17.91 | 517 / 527 |
liver | 100% | 2065.64 | 226 / 226 | 98% | 20.78 | 398 / 406 |
pancreas | 100% | 1937.47 | 328 / 328 | 98% | 21.64 | 174 / 178 |
ovary | 100% | 1754.33 | 180 / 180 | 97% | 14.73 | 417 / 430 |
lung | 100% | 1742.83 | 576 / 578 | 96% | 16.65 | 1111 / 1155 |
bladder | 100% | 1792.62 | 21 / 21 | 93% | 15.71 | 470 / 504 |
kidney | 100% | 1450.82 | 89 / 89 | 90% | 9.45 | 811 / 901 |
adrenal gland | 100% | 2882.22 | 258 / 258 | 90% | 11.58 | 207 / 230 |
uterus | 99% | 1143.44 | 168 / 170 | 88% | 12.05 | 402 / 459 |
skin | 87% | 694.11 | 1574 / 1809 | 99% | 23.19 | 468 / 472 |
esophagus | 84% | 1027.18 | 1221 / 1445 | 91% | 20.38 | 167 / 183 |
adipose | 100% | 1564.31 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 2504.37 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 32.81 | 1 / 1 |
eye | 0% | 0 | 0 / 0 | 99% | 19.61 | 79 / 80 |
lymph node | 0% | 0 | 0 / 0 | 97% | 10.32 | 28 / 29 |
heart | 92% | 826.07 | 788 / 861 | 0% | 0 | 0 / 0 |
blood vessel | 83% | 585.17 | 1103 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 77% | 930.83 | 713 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 76% | 6.16 | 34 / 45 |
muscle | 74% | 448.12 | 598 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006656 | Biological process | phosphatidylcholine biosynthetic process |
GO_0006629 | Biological process | lipid metabolic process |
GO_0006657 | Biological process | CDP-choline pathway |
GO_0006646 | Biological process | phosphatidylethanolamine biosynthetic process |
GO_0006869 | Biological process | lipid transport |
GO_0005829 | Cellular component | cytosol |
GO_0005811 | Cellular component | lipid droplet |
GO_0005737 | Cellular component | cytoplasm |
GO_0004713 | Molecular function | protein tyrosine kinase activity |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0004103 | Molecular function | choline kinase activity |
GO_0004104 | Molecular function | cholinesterase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0004305 | Molecular function | ethanolamine kinase activity |
Gene name | CHKA |
Protein name | ethanolamine kinase (EC 2.7.1.82) Choline kinase alpha (CK) (EC 2.7.1.32) (CHETK-alpha) (Ethanolamine kinase) (EK) (EC 2.7.1.82) |
Synonyms | CKI CHK |
Description | FUNCTION: Plays a key role in phospholipid biosynthesis by catalyzing the phosphorylation of free choline to phosphocholine, the first step in phosphatidylcholine biosynthesis . Also phosphorylates ethanolamine, thereby contributing to phosphatidylethanolamine biosynthesis . Has higher activity with choline . May contribute to tumor cell growth . .; FUNCTION: [Isoform 1]: This isoform plays a key role in lipolysis of lipid droplets following glucose deprivation . In response to glucose deprivation, phosphorylated by AMPK, promoting localization to lipid droplets . Phosphorylation is followed by acetylation by KAT5, leading to dissociation of the homodimer into a monomer . Monomeric CHKA isoform 1 is converted into a tyrosine-protein kinase, which phosphorylates lipid droplet structural proteins PLIN2 and PLIN3, leading to lipolysis of lipid droplets . . |
Accessions | E9PM06 ENST00000531341.1 ENST00000265689.9 [P35790-1] P35790 ENST00000356135.9 [P35790-2] H0YD02 ENST00000525155.5 |