CHKA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006656Biological processphosphatidylcholine biosynthetic process
GO_0006629Biological processlipid metabolic process
GO_0006657Biological processCDP-choline pathway
GO_0006646Biological processphosphatidylethanolamine biosynthetic process
GO_0006869Biological processlipid transport
GO_0005829Cellular componentcytosol
GO_0005811Cellular componentlipid droplet
GO_0005737Cellular componentcytoplasm
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0004103Molecular functioncholine kinase activity
GO_0004104Molecular functioncholinesterase activity
GO_0005524Molecular functionATP binding
GO_0004305Molecular functionethanolamine kinase activity

IV. Literature review

[source]
Gene nameCHKA
Protein nameethanolamine kinase (EC 2.7.1.82)
Choline kinase alpha (CK) (EC 2.7.1.32) (CHETK-alpha) (Ethanolamine kinase) (EK) (EC 2.7.1.82)
SynonymsCKI
CHK
DescriptionFUNCTION: Plays a key role in phospholipid biosynthesis by catalyzing the phosphorylation of free choline to phosphocholine, the first step in phosphatidylcholine biosynthesis . Also phosphorylates ethanolamine, thereby contributing to phosphatidylethanolamine biosynthesis . Has higher activity with choline . May contribute to tumor cell growth . .; FUNCTION: [Isoform 1]: This isoform plays a key role in lipolysis of lipid droplets following glucose deprivation . In response to glucose deprivation, phosphorylated by AMPK, promoting localization to lipid droplets . Phosphorylation is followed by acetylation by KAT5, leading to dissociation of the homodimer into a monomer . Monomeric CHKA isoform 1 is converted into a tyrosine-protein kinase, which phosphorylates lipid droplet structural proteins PLIN2 and PLIN3, leading to lipolysis of lipid droplets . .

AccessionsE9PM06
ENST00000531341.1
ENST00000265689.9 [P35790-1]
P35790
ENST00000356135.9 [P35790-2]
H0YD02
ENST00000525155.5