CHEK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042176Biological processregulation of protein catabolic process
GO_0044773Biological processmitotic DNA damage checkpoint signaling
GO_0006302Biological processdouble-strand break repair
GO_0006974Biological processDNA damage response
GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0006978Biological processDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO_0090399Biological processreplicative senescence
GO_0051301Biological processcell division
GO_0070242Biological processthymocyte apoptotic process
GO_0071480Biological processcellular response to gamma radiation
GO_0090307Biological processmitotic spindle assembly
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0050821Biological processprotein stabilization
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_2000785Biological processregulation of autophagosome assembly
GO_0006355Biological processregulation of DNA-templated transcription
GO_0030163Biological processprotein catabolic process
GO_0006977Biological processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0031573Biological processmitotic intra-S DNA damage checkpoint signaling
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0042770Biological processsignal transduction in response to DNA damage
GO_0000077Biological processDNA damage checkpoint signaling
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042802Molecular functionidentical protein binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCHEK2
Protein nameTruncated checkpoint kinase 2
Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2)
Serine/threonine-protein kinase Chk2
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase (EC 2.7.11.31) (Acetyl-CoA carboxylase kinase) (Hydroxymethylglutaryl-CoA reductase kinase)
Checkpoint kinase 2
SynonymsRAD53
CDS1
CHK2
DescriptionFUNCTION: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition . .; FUNCTION: (Microbial infection) Phosphorylates herpes simplex virus 1/HHV-1 protein ICP0 and thus activates its SUMO-targeted ubiquitin ligase activity. .

AccessionsENST00000649563.1 [O96017-13]
ENST00000425190
ENST00000439200.5
O96017
ENST00000434810.5
ENST00000711048.1
ENST00000456369.5
A0A7P0MUT5
ENST00000650281.1 [O96017-1]
B7ZBF2
ENST00000403642.5 [O96017-4]
ENST00000348295.7 [O96017-12]
ENST00000405598.5 [O96017-1]
H7C0V7
A0A3B3ITA7
H0Y4V6
H7BZ30
ENST00000464581.6
H0Y820
ENST00000425190.7 [O96017-13]
ENST00000448511.5 [O96017-6]
B7ZBF7
ENST00000439346.5
C9JFD7
ENST00000439346.6 [O96017-5]
ENST00000416671.5
A0A4P8PR71
ENST00000404276.6 [O96017-1]
ENST00000417588.5 [O96017-5]
ENST00000433728.5 [O96017-8]
F8WCV2
ENST00000398017.3
A0A087X102
A0A4V1ES41
A0AA34QVK6
ENST00000433028.6
ENST00000402731.6
B7ZBF8
ENST00000382580.6 [O96017-9]
ENST00000454252.2
ENST00000650233.1