CFI report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CFI at tissue level.

III. Associated gene sets

GO_0006958Biological processcomplement activation, classical pathway
GO_0006508Biological processproteolysis
GO_0045087Biological processinnate immune response
GO_0005615Cellular componentextracellular space
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameCFI
Protein nameComplement factor I
CFI protein
Complement factor I (EC 3.4.21.45) (C3B/C4B inactivator) [Cleaved into: Complement factor I heavy chain; Complement factor I light chain]
SynonymsIF
hCG_21044
DescriptionFUNCTION: Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins . Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces . The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization . .

AccessionsE7ETH0
ENST00000510800.1
Q8WW88
ENST00000512148.5
P05156
ENST00000394634.7
D6R9Z8
ENST00000394635.8
G3XAM2