Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 43 studies | 44% ± 19% | |
endothelial cell | 18 studies | 37% ± 19% | |
mesothelial cell | 14 studies | 51% ± 14% | |
basal cell | 13 studies | 31% ± 10% | |
connective tissue cell | 13 studies | 35% ± 17% | |
pericyte | 12 studies | 29% ± 9% | |
club cell | 11 studies | 29% ± 17% | |
ciliated cell | 10 studies | 25% ± 8% | |
smooth muscle cell | 8 studies | 24% ± 9% | |
myofibroblast cell | 8 studies | 52% ± 28% | |
endothelial cell of lymphatic vessel | 7 studies | 22% ± 4% | |
endothelial cell of artery | 7 studies | 29% ± 8% | |
hepatocyte | 6 studies | 86% ± 9% | |
respiratory goblet cell | 5 studies | 39% ± 16% | |
secretory cell | 5 studies | 31% ± 8% | |
adventitial cell | 5 studies | 55% ± 10% | |
adipocyte | 4 studies | 35% ± 17% | |
duct epithelial cell | 3 studies | 23% ± 4% | |
epithelial cell | 3 studies | 24% ± 11% | |
hepatic stellate cell | 3 studies | 71% ± 9% | |
retinal pigment epithelial cell | 3 studies | 26% ± 7% | |
vein endothelial cell | 3 studies | 17% ± 1% | |
cholangiocyte | 3 studies | 55% ± 25% | |
chondrocyte | 3 studies | 66% ± 17% | |
parietal epithelial cell | 3 studies | 73% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
liver | 100% | 57481.43 | 226 / 226 | 99% | 412.17 | 400 / 406 |
lung | 99% | 10769.96 | 572 / 578 | 91% | 40.25 | 1046 / 1155 |
thymus | 99% | 16313.77 | 649 / 653 | 81% | 47.62 | 493 / 605 |
breast | 97% | 8508.76 | 443 / 459 | 83% | 22.93 | 933 / 1118 |
esophagus | 85% | 6082.06 | 1235 / 1445 | 83% | 23.76 | 152 / 183 |
bladder | 95% | 14736.48 | 20 / 21 | 70% | 24.88 | 351 / 504 |
ovary | 100% | 22915.86 | 180 / 180 | 64% | 16.08 | 274 / 430 |
skin | 87% | 7187.07 | 1573 / 1809 | 60% | 22.97 | 283 / 472 |
stomach | 69% | 3457.27 | 249 / 359 | 64% | 18.39 | 182 / 286 |
intestine | 68% | 4561.83 | 655 / 966 | 50% | 13.19 | 265 / 527 |
adrenal gland | 83% | 4641.96 | 214 / 258 | 34% | 6.47 | 79 / 230 |
kidney | 37% | 2317.55 | 33 / 89 | 68% | 32.77 | 611 / 901 |
blood vessel | 100% | 30033.12 | 1335 / 1335 | 0% | 0 | 0 / 0 |
prostate | 52% | 2912.72 | 128 / 245 | 47% | 7.50 | 238 / 502 |
adipose | 99% | 15105.79 | 1191 / 1204 | 0% | 0 | 0 / 0 |
pancreas | 4% | 170.86 | 14 / 328 | 92% | 50.15 | 163 / 178 |
uterus | 21% | 857.36 | 36 / 170 | 68% | 27.87 | 314 / 459 |
tonsil | 0% | 0 | 0 / 0 | 87% | 32.84 | 39 / 45 |
lymph node | 0% | 0 | 0 / 0 | 83% | 16.53 | 24 / 29 |
heart | 67% | 16483.90 | 581 / 861 | 0% | 0 | 0 / 0 |
brain | 9% | 357.69 | 234 / 2642 | 31% | 7.60 | 221 / 705 |
muscle | 20% | 965.83 | 164 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 10% | 2.01 | 8 / 80 |
spleen | 7% | 331.83 | 18 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 3.41 | 1 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0030451 | Biological process | regulation of complement activation, alternative pathway |
GO_0006957 | Biological process | complement activation, alternative pathway |
GO_0006956 | Biological process | complement activation |
GO_0030449 | Biological process | regulation of complement activation |
GO_0006508 | Biological process | proteolysis |
GO_1903659 | Biological process | regulation of complement-dependent cytotoxicity |
GO_0106139 | Cellular component | symbiont cell surface |
GO_0005615 | Cellular component | extracellular space |
GO_0072562 | Cellular component | blood microparticle |
GO_1905370 | Cellular component | serine-type endopeptidase complex |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005576 | Cellular component | extracellular region |
GO_0001851 | Molecular function | complement component C3b binding |
GO_0043395 | Molecular function | heparan sulfate proteoglycan binding |
GO_0008201 | Molecular function | heparin binding |
GO_0005515 | Molecular function | protein binding |
GO_0042802 | Molecular function | identical protein binding |
Gene name | CFH |
Protein name | Complement factor H (H factor 1) Complement factor H |
Synonyms | HF2 HF1 HF |
Description | FUNCTION: Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces . Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop . As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b . In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed . .; FUNCTION: (Microbial infection) In the mosquito midgut, binds to the surface of parasite P.falciparum gametocytes and protects the parasite from alternative complement pathway-mediated elimination. . |
Accessions | ENST00000696030.1 A0A0D9SG88 A0A8Q3SI76 U5TZG9 A0A8Q3SIC3 ENST00000695978.1 A0A8Q3SID8 ENST00000695975.1 P08603 ENST00000696027.1 A0A8Q3SIE8 ENST00000695984.1 ENST00000695972.1 ENST00000695986.1 A0A8Q3WM65 A0A8Q3WLY2 A0A8Q3SIE0 A0A8Q3SI99 ENST00000695983.1 A0A8Q3WKW7 A0A8Q3WKX0 ENST00000696031.1 A0A8Q3WKX4 A0A8Q3SID7 A0A8Q3WM71 ENST00000630130.2 ENST00000696026.1 A0A8Q3WLF7 ENST00000367429.9 ENST00000695970.1 ENST00000695969.1 A0A8Q3SI73 ENST00000695981.1 ENST00000695973.1 ENST00000695968.1 A0A8Q3SJ41 A0A8Q3SIB6 A0A8Q3SI55 ENST00000695987.1 ENST00000696028.1 ENST00000695979.1 ENST00000696023.1 Q5TFM2 A0A8Q3SI78 ENST00000695971.1 A0A8Q3WKW2 A0A8Q3WKW6 ENST00000695974.1 A0A8Q3WKW3 ENST00000359637.3 A0A8Q3WL05 ENST00000695976.1 ENST00000696029.1 |