CFH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030451Biological processregulation of complement activation, alternative pathway
GO_0006957Biological processcomplement activation, alternative pathway
GO_0006956Biological processcomplement activation
GO_0030449Biological processregulation of complement activation
GO_0006508Biological processproteolysis
GO_1903659Biological processregulation of complement-dependent cytotoxicity
GO_0106139Cellular componentsymbiont cell surface
GO_0005615Cellular componentextracellular space
GO_0072562Cellular componentblood microparticle
GO_1905370Cellular componentserine-type endopeptidase complex
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0001851Molecular functioncomplement component C3b binding
GO_0043395Molecular functionheparan sulfate proteoglycan binding
GO_0008201Molecular functionheparin binding
GO_0005515Molecular functionprotein binding
GO_0042802Molecular functionidentical protein binding

IV. Literature review

[source]
Gene nameCFH
Protein nameComplement factor H (H factor 1)
Complement factor H
SynonymsHF2
HF1
HF
DescriptionFUNCTION: Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces . Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop . As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b . In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed . .; FUNCTION: (Microbial infection) In the mosquito midgut, binds to the surface of parasite P.falciparum gametocytes and protects the parasite from alternative complement pathway-mediated elimination. .

AccessionsENST00000696030.1
A0A0D9SG88
A0A8Q3SI76
U5TZG9
A0A8Q3SIC3
ENST00000695978.1
A0A8Q3SID8
ENST00000695975.1
P08603
ENST00000696027.1
A0A8Q3SIE8
ENST00000695984.1
ENST00000695972.1
ENST00000695986.1
A0A8Q3WM65
A0A8Q3WLY2
A0A8Q3SIE0
A0A8Q3SI99
ENST00000695983.1
A0A8Q3WKW7
A0A8Q3WKX0
ENST00000696031.1
A0A8Q3WKX4
A0A8Q3SID7
A0A8Q3WM71
ENST00000630130.2
ENST00000696026.1
A0A8Q3WLF7
ENST00000367429.9
ENST00000695970.1
ENST00000695969.1
A0A8Q3SI73
ENST00000695981.1
ENST00000695973.1
ENST00000695968.1
A0A8Q3SJ41
A0A8Q3SIB6
A0A8Q3SI55
ENST00000695987.1
ENST00000696028.1
ENST00000695979.1
ENST00000696023.1
Q5TFM2
A0A8Q3SI78
ENST00000695971.1
A0A8Q3WKW2
A0A8Q3WKW6
ENST00000695974.1
A0A8Q3WKW3
ENST00000359637.3
A0A8Q3WL05
ENST00000695976.1
ENST00000696029.1