CDK9 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CDK9 at tissue level.

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0120187Biological processpositive regulation of protein localization to chromatin
GO_0006281Biological processDNA repair
GO_0008283Biological processcell population proliferation
GO_0140673Biological processtranscription elongation-coupled chromatin remodeling
GO_0051147Biological processregulation of muscle cell differentiation
GO_0006282Biological processregulation of DNA repair
GO_0051647Biological processnucleus localization
GO_0006368Biological processtranscription elongation by RNA polymerase II
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0120186Biological processnegative regulation of protein localization to chromatin
GO_0031297Biological processreplication fork processing
GO_0071345Biological processcellular response to cytokine stimulus
GO_0043923Biological processpositive regulation by host of viral transcription
GO_0007346Biological processregulation of mitotic cell cycle
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0006468Biological processprotein phosphorylation
GO_0051726Biological processregulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0031440Biological processregulation of mRNA 3'-end processing
GO_0008024Cellular componentcyclin/CDK positive transcription elongation factor complex
GO_0008023Cellular componenttranscription elongation factor complex
GO_0016020Cellular componentmembrane
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0005654Cellular componentnucleoplasm
GO_0016605Cellular componentPML body
GO_0070691Cellular componentP-TEFb complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0003682Molecular functionchromatin binding
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0001223Molecular functiontranscription coactivator binding
GO_0008353Molecular functionRNA polymerase II CTD heptapeptide repeat kinase activity
GO_0097322Molecular function7SK snRNA binding
GO_0005524Molecular functionATP binding
GO_0003711Molecular functiontranscription elongation factor activity
GO_0016301Molecular functionkinase activity
GO_0005515Molecular functionprotein binding
GO_0004693Molecular functioncyclin-dependent protein serine/threonine kinase activity

IV. Literature review

[source]
Gene nameCDK9
Protein nameCyclin-dependent kinase 9
Cyclin dependent kinase 9
Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit)
SynonymsCDC2L4
TAK
DescriptionFUNCTION: Protein kinase involved in the regulation of transcription . Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP . This complex is inactive when in the 7SK snRNP complex form . Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELFE . Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling) . Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis . P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export . Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing . The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro . Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage . In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6 . Promotes cardiac myocyte enlargement . RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription . AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect . The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation . Catalyzes phosphorylation of KAT5, promoting KAT5 recruitment to chromatin and histone acetyltransferase activity . .

AccessionsX6RE90
P50750
B5BU53
ENST00000421939.5
ENST00000373264.5 [P50750-1]