CCNB1IP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007131Biological processreciprocal meiotic recombination
GO_0016567Biological processprotein ubiquitination
GO_0051026Biological processchiasma assembly
GO_0001825Biological processblastocyst formation
GO_0007286Biological processspermatid development
GO_0000795Cellular componentsynaptonemal complex
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameCCNB1IP1
Protein nameE3 ubiquitin-protein ligase CCNB1IP1 (EC 2.3.2.27) (Cyclin-B1-interacting protein 1) (Human enhancer of invasion 10) (RING-type E3 ubiquitin transferase CCNB1IP1)
Cyclin B1 interacting protein 1
Cyclin B1 interacting protein 1 (Epididymis secretory sperm binding protein)
SynonymsC14orf18
HEI10
hCG_40484
DescriptionFUNCTION: Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. .; FUNCTION: E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.

AccessionsQ9NPC3
ENST00000708737.1
ENST00000398163.6
ENST00000353689.8
ENST00000554047.1
ENST00000398169.7
ENST00000708741.1
ENST00000708742.1
ENST00000557665.5
ENST00000398160.6
G3V5Q4
ENST00000556854.5
ENST00000556563.5
G3V5S3
ENST00000554184.5
H0YJB2
H0YJ70
ENST00000708738.1
ENST00000708739.1
ENST00000708740.1
ENST00000358932.9
A0A384MR52
G3V5E6