CCDC88B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050870Biological processpositive regulation of T cell activation
GO_0042102Biological processpositive regulation of T cell proliferation
GO_0001819Biological processpositive regulation of cytokine production
GO_0030705Biological processcytoskeleton-dependent intracellular transport
GO_0031122Biological processcytoplasmic microtubule organization
GO_0042832Biological processdefense response to protozoan
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005783Cellular componentendoplasmic reticulum
GO_0005794Cellular componentGolgi apparatus
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0051959Molecular functiondynein light intermediate chain binding
GO_0005515Molecular functionprotein binding
GO_0008017Molecular functionmicrotubule binding

IV. Literature review

[source]
Gene nameCCDC88B
Protein nameCoiled-coil domain-containing protein 88B (Brain leucine zipper domain-containing protein) (Gipie) (Hook-related protein 3) (HkRP3)
Coiled-coil domain containing 88B
SynonymsBRLZ
DescriptionFUNCTION: Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation (By similarity). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC . Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis . .

AccessionsB2RTU8
ENST00000359902.2
H7BY33
ENST00000301897.5 [A6NC98-6]
A6NC98
ENST00000356786.10 [A6NC98-1]