CACTIN report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CACTIN at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CACTIN at tissue level.

III. Associated gene sets

GO_0045087Biological processinnate immune response
GO_0071347Biological processcellular response to interleukin-1
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0045824Biological processnegative regulation of innate immune response
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0032717Biological processnegative regulation of interleukin-8 production
GO_0034122Biological processnegative regulation of toll-like receptor signaling pathway
GO_0045292Biological processmRNA cis splicing, via spliceosome
GO_0032688Biological processnegative regulation of interferon-beta production
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0031665Biological processnegative regulation of lipopolysaccharide-mediated signaling pathway
GO_0060339Biological processnegative regulation of type I interferon-mediated signaling pathway
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0005681Cellular componentspliceosomal complex
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0005634Cellular componentnucleus
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCACTIN
Protein nameSplicing factor Cactin (Renal carcinoma antigen NY-REN-24)
Cactin, spliceosome C complex subunit
SynonymsC19orf29
DescriptionFUNCTION: Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns . Required for the splicing of CDCA5/Sororin, a regulator of sister chromatid cohesion . Involved in the regulation of innate immune response . Acts as a negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways . Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli . .

AccessionsQ8WUQ7
ENST00000585942.5 [Q8WUQ7-1]
K7EMQ0
ENST00000591726.1
K7EQE3
ENST00000248420.9 [Q8WUQ7-1]
ENST00000429344.7 [Q8WUQ7-1]
ENST00000592721.5
K7EIU6
K7ENY9
ENST00000589321.5
ENST00000221899.7 [Q8WUQ7-1]
ENST00000588749.1