C4BPA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045732Biological processpositive regulation of protein catabolic process
GO_0002456Biological processT cell mediated immunity
GO_0006958Biological processcomplement activation, classical pathway
GO_0009609Biological processresponse to symbiotic bacterium
GO_1903027Biological processregulation of opsonization
GO_0045959Biological processnegative regulation of complement activation, classical pathway
GO_0045087Biological processinnate immune response
GO_0005615Cellular componentextracellular space
GO_0072562Cellular componentblood microparticle
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameC4BPA
Protein nameC4b-binding protein alpha chain (C4bp) (Proline-rich protein) (PRP)
Complement component 4 binding protein alpha
SynonymsC4BP
DescriptionFUNCTION: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.

AccessionsA6PVY5
ENST00000424088.1
P04003
ENST00000421786.5
F2Z2V7
ENST00000367070.8