C2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of C2 at tissue level.

III. Associated gene sets

GO_0007584Biological processresponse to nutrient
GO_0006958Biological processcomplement activation, classical pathway
GO_0006956Biological processcomplement activation
GO_0006508Biological processproteolysis
GO_0097066Biological processresponse to thyroid hormone
GO_2000427Biological processpositive regulation of apoptotic cell clearance
GO_0032496Biological processresponse to lipopolysaccharide
GO_0045087Biological processinnate immune response
GO_0009617Biological processresponse to bacterium
GO_0005615Cellular componentextracellular space
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameC2
Protein nameComplement C2
Complement C2 (EC 3.4.21.43) (C3/C5 convertase)
Complement C2 (EC 3.4.21.43) (C3/C5 convertase) [Cleaved into: Complement C2b fragment; Complement C2a fragment]
Complement protein
C3/C5 convertase
Complement component C2
SynonymshCG_43694
DescriptionFUNCTION: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.

FUNCTION: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. .

FUNCTION: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. .

FUNCTION: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. .

FUNCTION: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. .

FUNCTION: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. .

FUNCTION: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. .

FUNCTION: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. .

FUNCTION: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. .

FUNCTION: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. .

FUNCTION: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. .

AccessionsENST00000416456.5
ENST00000613837.3
ENST00000457446.5
F2Z3N2
ENST00000482060.5
ENST00000418949.6
B4DQI1
ENST00000551081.4 [P06681-3]
ENST00000435104.5
ENST00000411803.6 [P06681-1]
ENST00000452763.5
ENST00000411830.5
A0A0G2JHM4
ENST00000383359.7
ENST00000550363.4
ENST00000458410.5
A2ABG0
ENST00000548250.5
ENST00000413548.6 [P06681-1]
ENST00000618948.4
ENST00000446097.5
ENST00000695638.1
ENST00000433109.5
H0Y868
A0A0G2JI59
H0Y3H6
F8WCJ9
ENST00000550682.5 [P06681-3]
Q86SV5
ENST00000445056.1
A0A0G2JK28
Q6LBG4
ENST00000435596.5
ENST00000551648.5 [P06681-3]
ENST00000614291.3
ENST00000428140.5
ENST00000383362.8 [P06681-1]
ENST00000447164.1
ENST00000415985.5
Q5ST52
ENST00000548500.4
ENST00000423826.5
Q95IG1
ENST00000494905.1
ENST00000484636.1
ENST00000416252.6 [P06681-1]
ENST00000615801.3
A0A0G2JL69
ENST00000448206.6 [P06681-1]
ENST00000422470.5
ENST00000383367.6
ENST00000452202.5
ENST00000618254.4 [P06681-2]
F2Z306
ENST00000439426.5
ENST00000550045.5
ENST00000299367.10 [P06681-1]
ENST00000621558.4 [P06681-2]
Q8N6L6
ENST00000449738.5
ENST00000437162.5
ENST00000612228.1 [P06681-2]
E9PDZ0
ENST00000549997.5
A0A8Q3WL70
ENST00000695637.1
ENST00000440861.1
ENST00000468407.2
ENST00000375510.8 [P06681-1]
ENST00000411885.5
ENST00000552638.3
ENST00000411571.6
ENST00000419062.5
ENST00000469372.5
P06681
ENST00000417322.5
ENST00000455713.5
ENST00000458436.5
ENST00000428349.5
ENST00000449293.1
ENST00000548973.5 [P06681-3]
ENST00000452323.7 [P06681-2]
A0A8Q3WKM6
ENST00000447952.7
ENST00000383177.7
A0A0G2JJM0
ENST00000413649.1
C9JYQ5
ENST00000413154.5
ENST00000548995.3 [P06681-3]
ENST00000432285.5
ENST00000437394.1
ENST00000548828.4
ENST00000418584.5
ENST00000431247.5
ENST00000436560.5
A0A8Q3WKN5
Q6LDG4
A0A0G2JJ82
ENST00000442278.6 [P06681-3]
A0A0G2JIE7
ENST00000615380.4 [P06681-2]
A0A8Q3WKM9
ENST00000695644.1
ENST00000421932.5
ENST00000485690.5
ENST00000414609.5
ENST00000549972.3 [P06681-3]
ENST00000547984.3
Q5JP69
ENST00000497706.6