BRSK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030010Biological processestablishment of cell polarity
GO_0070059Biological processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_2000807Biological processregulation of synaptic vesicle clustering
GO_0043462Biological processregulation of ATP-dependent activity
GO_0051301Biological processcell division
GO_1904152Biological processregulation of retrograde protein transport, ER to cytosol
GO_0007409Biological processaxonogenesis
GO_0090176Biological processmicrotubule cytoskeleton organization involved in establishment of planar polarity
GO_0030182Biological processneuron differentiation
GO_0030036Biological processactin cytoskeleton organization
GO_0006887Biological processexocytosis
GO_0061178Biological processregulation of insulin secretion involved in cellular response to glucose stimulus
GO_0010975Biological processregulation of neuron projection development
GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0006468Biological processprotein phosphorylation
GO_0036503Biological processERAD pathway
GO_0050770Biological processregulation of axonogenesis
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0150034Cellular componentdistal axon
GO_0005813Cellular componentcentrosome
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0106310Molecular functionprotein serine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0060590Molecular functionATPase regulator activity
GO_0050321Molecular functiontau-protein kinase activity
GO_0005524Molecular functionATP binding
GO_0048156Molecular functiontau protein binding
GO_0051117Molecular functionATPase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBRSK2
Protein nameBR serine/threonine kinase 2, isoform CRA_a (Testicular tissue protein Li 30)
Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A)
BR serine/threonine kinase 2
SynonymsSADA
hCG_1778319
STK29
C11orf7
HUSSY-12
PEN11B
DescriptionFUNCTION: Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion , BRSK2 phosphorylated at Thr-260 can promote insulin secretion . Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. .

AccessionsENST00000524702.5
ENST00000544817.5
ENST00000528710.5 [Q8IWQ3-6]
E9PRY3
ENST00000707533.1 [Q8IWQ3-3]
ENST00000528841.6 [Q8IWQ3-1]
H0YCS6
ENST00000707536.1 [Q8IWQ3-2]
ENST00000529951.5
Q8IWQ3
ENST00000707534.1 [Q8IWQ3-2]
ENST00000707535.1 [Q8IWQ3-1]
A0A140VJF6
ENST00000707540.1 [Q8IWQ3-6]
ENST00000531197.5 [Q8IWQ3-2]
H0YES6
ENST00000707541.1 [Q8IWQ3-5]
ENST00000533606.2
ENST00000528596.5
A0A0C4DGH9
E9PPI2
ENST00000529433.5 [Q8IWQ3-2]
ENST00000526678.5 [Q8IWQ3-4]
ENST00000707537.1 [Q8IWQ3-4]
ENST00000382179.5 [Q8IWQ3-5]
ENST00000308219.13 [Q8IWQ3-3]