Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 16 studies | 51% ± 20% | |
| endothelial cell | 12 studies | 29% ± 14% | |
| oligodendrocyte precursor cell | 11 studies | 34% ± 16% | |
| oligodendrocyte | 11 studies | 29% ± 12% | |
| glutamatergic neuron | 10 studies | 35% ± 24% | |
| microglial cell | 9 studies | 27% ± 10% | |
| adipocyte | 9 studies | 44% ± 13% | |
| GABAergic neuron | 7 studies | 43% ± 21% | |
| epithelial cell | 7 studies | 34% ± 17% | |
| fibroblast | 7 studies | 27% ± 12% | |
| interneuron | 6 studies | 42% ± 25% | |
| basal cell | 5 studies | 29% ± 19% | |
| neuron | 4 studies | 32% ± 15% | |
| granule cell | 4 studies | 24% ± 3% | |
| cardiac muscle cell | 4 studies | 36% ± 6% | |
| goblet cell | 4 studies | 36% ± 19% | |
| club cell | 4 studies | 23% ± 10% | |
| endothelial cell of lymphatic vessel | 4 studies | 21% ± 2% | |
| type II pneumocyte | 4 studies | 22% ± 7% | |
| smooth muscle cell | 4 studies | 23% ± 5% | |
| GABAergic interneuron | 3 studies | 28% ± 6% | |
| macrophage | 3 studies | 31% ± 6% | |
| hepatocyte | 3 studies | 58% ± 19% | |
| ependymal cell | 3 studies | 43% ± 27% | |
| type I pneumocyte | 3 studies | 21% ± 6% | |
| pericyte | 3 studies | 21% ± 7% | |
| transit amplifying cell | 3 studies | 39% ± 32% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 1702.42 | 180 / 180 | 100% | 18.62 | 430 / 430 |
| prostate | 100% | 1380.75 | 245 / 245 | 100% | 29.99 | 501 / 502 |
| stomach | 100% | 1644.31 | 359 / 359 | 99% | 20.16 | 284 / 286 |
| brain | 99% | 1073.96 | 2627 / 2642 | 100% | 30.06 | 704 / 705 |
| intestine | 100% | 1536.57 | 966 / 966 | 99% | 22.32 | 523 / 527 |
| breast | 100% | 1596.58 | 459 / 459 | 99% | 20.71 | 1108 / 1118 |
| thymus | 100% | 1319.53 | 653 / 653 | 98% | 17.01 | 594 / 605 |
| pancreas | 99% | 840.07 | 326 / 328 | 98% | 13.29 | 175 / 178 |
| lung | 99% | 856.78 | 570 / 578 | 99% | 14.00 | 1140 / 1155 |
| bladder | 100% | 1553.52 | 21 / 21 | 97% | 18.62 | 489 / 504 |
| kidney | 100% | 1444.49 | 89 / 89 | 96% | 18.22 | 869 / 901 |
| esophagus | 100% | 1290.39 | 1445 / 1445 | 96% | 14.33 | 176 / 183 |
| liver | 100% | 2572.01 | 226 / 226 | 95% | 18.38 | 385 / 406 |
| uterus | 100% | 1236.03 | 170 / 170 | 93% | 13.75 | 428 / 459 |
| adrenal gland | 100% | 1218.99 | 258 / 258 | 92% | 14.04 | 212 / 230 |
| skin | 100% | 1059.66 | 1802 / 1809 | 91% | 12.38 | 431 / 472 |
| adipose | 100% | 1472.66 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1642.34 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 577.66 | 241 / 241 | 0% | 0 | 0 / 0 |
| heart | 94% | 1159.05 | 809 / 861 | 0% | 0 | 0 / 0 |
| muscle | 94% | 514.68 | 753 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 90% | 9.33 | 26 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 13.63 | 39 / 45 |
| eye | 0% | 0 | 0 / 0 | 83% | 9.27 | 66 / 80 |
| peripheral blood | 30% | 457.12 | 282 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007584 | Biological process | response to nutrient |
| GO_0051591 | Biological process | response to cAMP |
| GO_0051384 | Biological process | response to glucocorticoid |
| GO_0006629 | Biological process | lipid metabolic process |
| GO_0009083 | Biological process | branched-chain amino acid catabolic process |
| GO_0005730 | Cellular component | nucleolus |
| GO_0160157 | Cellular component | branched-chain alpha-ketoacid dehydrogenase complex |
| GO_0045252 | Cellular component | oxoglutarate dehydrogenase complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_0047101 | Molecular function | branched-chain alpha-keto acid dehydrogenase activity |
| GO_0003863 | Molecular function | 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | BCKDHB |
| Protein name | 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (EC 1.2.4.4) 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDE1B) (BCKDH E1-beta) |
| Synonyms | |
| Description | FUNCTION: Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. . |
| Accessions | ENST00000356489.9 [P21953-1] ENST00000320393.9 [P21953-1] ENST00000369760.8 [P21953-2] P21953 A0A0K2GN21 |