ATP8A2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	13 studies	72% ± 21%	Explore
GABAergic neuron	10 studies	72% ± 21%	Explore
oligodendrocyte precursor cell	10 studies	30% ± 13%	Explore
retinal ganglion cell	7 studies	69% ± 24%	Explore
interneuron	6 studies	68% ± 27%	Explore
neuron	5 studies	47% ± 12%	Explore
retinal cone cell	5 studies	63% ± 26%	Explore
endothelial cell	4 studies	44% ± 22%	Explore
granule cell	4 studies	71% ± 20%	Explore
microglial cell	4 studies	32% ± 17%	Explore
amacrine cell	4 studies	37% ± 10%	Explore
retinal rod cell	4 studies	76% ± 12%	Explore
GABAergic interneuron	3 studies	86% ± 1%	Explore
GABAergic amacrine cell	3 studies	38% ± 19%	Explore
OFF-bipolar cell	3 studies	46% ± 30%	Explore
ON-bipolar cell	3 studies	62% ± 23%	Explore
glycinergic amacrine cell	3 studies	34% ± 12%	Explore
retina horizontal cell	3 studies	35% ± 20%	Explore
astrocyte	3 studies	35% ± 28%	Explore
oligodendrocyte	3 studies	36% ± 23%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	43% ± 25%	Explore
eye	5 studies	43% ± 23%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	95%	3748.25	2507 / 2642	70%	5.82	497 / 705
adrenal gland	76%	609.03	195 / 258	63%	14.86	146 / 230
lung	45%	225.47	259 / 578	35%	1.24	404 / 1155
skin	2%	8.10	30 / 1809	63%	5.68	298 / 472
prostate	0%	1.17	1 / 245	56%	5.47	281 / 502
kidney	15%	60.40	13 / 89	37%	0.91	329 / 901
breast	4%	21.17	17 / 459	41%	3.14	460 / 1118
stomach	29%	119.81	103 / 359	4%	0.11	11 / 286
pancreas	0%	0	0 / 328	29%	1.38	51 / 178
thymus	0%	1.18	1 / 653	28%	0.88	167 / 605
bladder	14%	73.00	3 / 21	12%	0.71	60 / 504
intestine	20%	77.28	195 / 966	4%	0.09	19 / 527
uterus	5%	43.87	8 / 170	16%	0.72	75 / 459
ovary	9%	47.84	17 / 180	11%	0.27	47 / 430
tonsil	0%	0	0 / 0	20%	0.54	9 / 45
lymph node	0%	0	0 / 0	17%	0.58	5 / 29
esophagus	2%	6.38	27 / 1445	13%	0.66	24 / 183
eye	0%	0	0 / 0	6%	0.23	5 / 80
liver	0%	0	0 / 226	6%	0.56	24 / 406
blood vessel	2%	9.17	29 / 1335	0%	0	0 / 0
spleen	1%	3.41	3 / 241	0%	0	0 / 0
heart	1%	1.92	5 / 861	0%	0	0 / 0
muscle	0%	1.01	2 / 803	0%	0	0 / 0
adipose	0%	0.60	2 / 1204	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0140331	Biological process	aminophospholipid translocation
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0010996	Biological process	response to auditory stimulus
GO_0060052	Biological process	neurofilament cytoskeleton organization
GO_0010976	Biological process	positive regulation of neuron projection development
GO_0008340	Biological process	determination of adult lifespan
GO_0061092	Biological process	positive regulation of phospholipid translocation
GO_0003011	Biological process	involuntary skeletal muscle contraction
GO_0050884	Biological process	neuromuscular process controlling posture
GO_0007409	Biological process	axonogenesis
GO_0050908	Biological process	detection of light stimulus involved in visual perception
GO_0048666	Biological process	neuron development
GO_0042755	Biological process	eating behavior
GO_0045332	Biological process	phospholipid translocation
GO_0042472	Biological process	inner ear morphogenesis
GO_0043588	Biological process	skin development
GO_0040018	Biological process	positive regulation of multicellular organism growth
GO_0010842	Biological process	retina layer formation
GO_0005886	Cellular component	plasma membrane
GO_0005654	Cellular component	nucleoplasm
GO_0005794	Cellular component	Golgi apparatus
GO_0000139	Cellular component	Golgi membrane
GO_1990531	Cellular component	phospholipid-translocating ATPase complex
GO_0042995	Cellular component	cell projection
GO_0010008	Cellular component	endosome membrane
GO_0090556	Molecular function	phosphatidylserine floppase activity
GO_0140326	Molecular function	ATPase-coupled intramembrane lipid transporter activity
GO_0000287	Molecular function	magnesium ion binding
GO_0090555	Molecular function	phosphatidylethanolamine flippase activity
GO_0005524	Molecular function	ATP binding
GO_0140346	Molecular function	phosphatidylserine flippase activity
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	ATP8A2
Protein name	ATPase phospholipid transporting 8A2 Phospholipid-transporting ATPase IB (EC 7.6.2.1) (ATPase class I type 8A member 2) (ML-1) (P4-ATPase flippase complex alpha subunit ATP8A2) Phospholipid-transporting ATPase (EC 7.6.2.1)
Synonyms	ATPIB
Description	FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (By similarity). Able to translocate phosphatidylserine, but not phosphatidylcholine . Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity). Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE) (By similarity). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP (By similarity). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth (By similarity). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes (By similarity). May be involved in vesicle trafficking in neuronal cells (By similarity). Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival (By similarity). .
Accessions	A0A804HKN1 ENST00000683303.1 Q9NTI2 F8W9B3 ENST00000684424.1 [Q9NTI2-1] A0A804HJ19 ENST00000683960.1 A0A804HLG3 ENST00000381655.7 [Q9NTI2-4] ENST00000682943.1 A0A804HI09 A0A804HKW9 ENST00000281620.11 ENST00000682472.1 ENST00000684283.1

ATP8A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review