Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 16 studies | 26% ± 10% | |
microglial cell | 9 studies | 30% ± 10% | |
macrophage | 7 studies | 28% ± 8% | |
endothelial cell of lymphatic vessel | 5 studies | 24% ± 8% | |
GABAergic neuron | 5 studies | 25% ± 9% | |
astrocyte | 5 studies | 27% ± 12% | |
interneuron | 4 studies | 26% ± 12% | |
vein endothelial cell | 4 studies | 32% ± 22% | |
smooth muscle cell | 4 studies | 18% ± 2% | |
neuron | 3 studies | 29% ± 2% | |
oligodendrocyte precursor cell | 3 studies | 22% ± 4% | |
hepatocyte | 3 studies | 39% ± 16% | |
fibroblast | 3 studies | 22% ± 3% | |
glutamatergic neuron | 3 studies | 32% ± 16% | |
oligodendrocyte | 3 studies | 25% ± 8% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 5 studies | 27% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1472.58 | 1442 / 1445 | 98% | 13.69 | 180 / 183 |
breast | 100% | 2236.27 | 459 / 459 | 97% | 13.71 | 1089 / 1118 |
prostate | 100% | 1939.49 | 245 / 245 | 97% | 11.26 | 486 / 502 |
kidney | 100% | 1495.91 | 89 / 89 | 96% | 15.30 | 867 / 901 |
bladder | 100% | 2545.19 | 21 / 21 | 96% | 12.20 | 484 / 504 |
lung | 99% | 1505.38 | 575 / 578 | 97% | 11.89 | 1115 / 1155 |
intestine | 100% | 1816.09 | 966 / 966 | 94% | 9.78 | 498 / 527 |
thymus | 100% | 1357.63 | 652 / 653 | 93% | 7.28 | 564 / 605 |
uterus | 100% | 2789.06 | 170 / 170 | 93% | 11.57 | 427 / 459 |
stomach | 100% | 1267.24 | 359 / 359 | 93% | 11.03 | 266 / 286 |
skin | 100% | 1756.90 | 1807 / 1809 | 87% | 10.55 | 409 / 472 |
ovary | 100% | 2444.02 | 180 / 180 | 85% | 6.42 | 364 / 430 |
liver | 100% | 2310.57 | 226 / 226 | 84% | 9.30 | 340 / 406 |
pancreas | 90% | 532.83 | 294 / 328 | 93% | 9.13 | 166 / 178 |
adrenal gland | 100% | 1423.69 | 258 / 258 | 79% | 5.59 | 182 / 230 |
brain | 76% | 502.14 | 1998 / 2642 | 91% | 6.38 | 642 / 705 |
adipose | 100% | 2578.11 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2543.09 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 1912.80 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.19 | 1 / 1 |
tonsil | 0% | 0 | 0 / 0 | 98% | 12.93 | 44 / 45 |
lymph node | 0% | 0 | 0 / 0 | 97% | 12.40 | 28 / 29 |
heart | 83% | 587.33 | 717 / 861 | 0% | 0 | 0 / 0 |
muscle | 72% | 417.19 | 576 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 64% | 1093.00 | 598 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 55% | 3.66 | 44 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0140331 | Biological process | aminophospholipid translocation |
GO_0034220 | Biological process | monoatomic ion transmembrane transport |
GO_0045332 | Biological process | phospholipid translocation |
GO_0005886 | Cellular component | plasma membrane |
GO_0055037 | Cellular component | recycling endosome |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0031901 | Cellular component | early endosome membrane |
GO_0055038 | Cellular component | recycling endosome membrane |
GO_1990531 | Cellular component | phospholipid-translocating ATPase complex |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0090556 | Molecular function | phosphatidylserine floppase activity |
GO_0140326 | Molecular function | ATPase-coupled intramembrane lipid transporter activity |
GO_0000287 | Molecular function | magnesium ion binding |
GO_0090555 | Molecular function | phosphatidylethanolamine flippase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0140346 | Molecular function | phosphatidylserine flippase activity |
GO_0005515 | Molecular function | protein binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
Gene name | ATP11C |
Protein name | Phospholipid-transporting ATPase IG (EC 7.6.2.1) (ATPase IQ) (ATPase class VI type 11C) (P4-ATPase flippase complex alpha subunit ATP11C) ATPase phospholipid transporting 11C Phospholipid-transporting ATPase (EC 7.6.2.1) |
Synonyms | ATPIQ ATPIG |
Description | FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane . Major PS-flippase in immune cell subsets. In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages . Required for B cell differentiation past the pro-B cell stage (By similarity). Seems to mediate PS flipping in pro-B cells (By similarity). May be involved in the transport of cholestatic bile acids (By similarity). . |
Accessions | A0A067XG57 H7C113 ENST00000433868.5 H7C0E8 ENST00000422228.2 ENST00000327569.7 [Q8NB49-1] A0A067XG54 ENST00000450801.1 ENST00000361648.6 [Q8NB49-3] A0A804HIW2 ENST00000370557.5 ENST00000682941.1 Q8NB49 |