ATP11C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140331Biological processaminophospholipid translocation
GO_0034220Biological processmonoatomic ion transmembrane transport
GO_0045332Biological processphospholipid translocation
GO_0005886Cellular componentplasma membrane
GO_0055037Cellular componentrecycling endosome
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0031901Cellular componentearly endosome membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_1990531Cellular componentphospholipid-translocating ATPase complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0005765Cellular componentlysosomal membrane
GO_0090556Molecular functionphosphatidylserine floppase activity
GO_0140326Molecular functionATPase-coupled intramembrane lipid transporter activity
GO_0000287Molecular functionmagnesium ion binding
GO_0090555Molecular functionphosphatidylethanolamine flippase activity
GO_0005524Molecular functionATP binding
GO_0140346Molecular functionphosphatidylserine flippase activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameATP11C
Protein namePhospholipid-transporting ATPase IG (EC 7.6.2.1) (ATPase IQ) (ATPase class VI type 11C) (P4-ATPase flippase complex alpha subunit ATP11C)
ATPase phospholipid transporting 11C
Phospholipid-transporting ATPase (EC 7.6.2.1)
SynonymsATPIQ
ATPIG
DescriptionFUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane . Major PS-flippase in immune cell subsets. In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages . Required for B cell differentiation past the pro-B cell stage (By similarity). Seems to mediate PS flipping in pro-B cells (By similarity). May be involved in the transport of cholestatic bile acids (By similarity). .

AccessionsA0A067XG57
H7C113
ENST00000433868.5
H7C0E8
ENST00000422228.2
ENST00000327569.7 [Q8NB49-1]
A0A067XG54
ENST00000450801.1
ENST00000361648.6 [Q8NB49-3]
A0A804HIW2
ENST00000370557.5
ENST00000682941.1
Q8NB49