Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 14 studies | 29% ± 11% | |
astrocyte | 12 studies | 39% ± 17% | |
oligodendrocyte precursor cell | 12 studies | 33% ± 12% | |
oligodendrocyte | 12 studies | 32% ± 13% | |
glutamatergic neuron | 11 studies | 41% ± 23% | |
microglial cell | 10 studies | 36% ± 11% | |
GABAergic neuron | 9 studies | 42% ± 21% | |
type I pneumocyte | 8 studies | 24% ± 7% | |
macrophage | 7 studies | 28% ± 8% | |
neuron | 6 studies | 33% ± 10% | |
interneuron | 6 studies | 47% ± 24% | |
epithelial cell | 6 studies | 36% ± 14% | |
fibroblast | 6 studies | 26% ± 10% | |
basal cell | 6 studies | 28% ± 14% | |
retinal ganglion cell | 5 studies | 35% ± 16% | |
retina horizontal cell | 5 studies | 19% ± 4% | |
type II pneumocyte | 5 studies | 21% ± 4% | |
club cell | 5 studies | 25% ± 4% | |
adipocyte | 4 studies | 20% ± 4% | |
endothelial cell of lymphatic vessel | 4 studies | 24% ± 4% | |
pericyte | 4 studies | 23% ± 6% | |
hepatocyte | 4 studies | 47% ± 14% | |
GABAergic interneuron | 3 studies | 38% ± 5% | |
granule cell | 3 studies | 22% ± 4% | |
retinal pigment epithelial cell | 3 studies | 23% ± 6% | |
CD4-positive, alpha-beta T cell | 3 studies | 22% ± 2% | |
cardiac muscle cell | 3 studies | 22% ± 6% | |
ciliated cell | 3 studies | 19% ± 2% | |
abnormal cell | 3 studies | 27% ± 11% | |
ependymal cell | 3 studies | 31% ± 13% | |
lymphocyte | 3 studies | 38% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 6289.73 | 1445 / 1445 | 100% | 45.14 | 183 / 183 |
prostate | 100% | 5237.09 | 245 / 245 | 100% | 33.51 | 500 / 502 |
breast | 100% | 5519.20 | 459 / 459 | 100% | 60.82 | 1113 / 1118 |
thymus | 100% | 5581.13 | 653 / 653 | 99% | 35.00 | 601 / 605 |
liver | 100% | 5145.51 | 226 / 226 | 99% | 26.51 | 403 / 406 |
intestine | 100% | 6208.96 | 966 / 966 | 99% | 25.73 | 522 / 527 |
brain | 100% | 9635.07 | 2641 / 2642 | 99% | 55.42 | 698 / 705 |
skin | 100% | 6481.78 | 1806 / 1809 | 98% | 35.65 | 464 / 472 |
stomach | 100% | 4056.62 | 358 / 359 | 98% | 30.38 | 281 / 286 |
uterus | 100% | 5252.25 | 170 / 170 | 98% | 30.98 | 449 / 459 |
lung | 99% | 4721.97 | 574 / 578 | 98% | 31.52 | 1136 / 1155 |
kidney | 100% | 4532.52 | 89 / 89 | 97% | 32.29 | 878 / 901 |
bladder | 100% | 5875.71 | 21 / 21 | 96% | 23.31 | 484 / 504 |
adrenal gland | 100% | 4276.96 | 258 / 258 | 95% | 27.73 | 219 / 230 |
ovary | 100% | 5117.08 | 180 / 180 | 94% | 25.08 | 406 / 430 |
pancreas | 95% | 2453.24 | 310 / 328 | 98% | 23.67 | 175 / 178 |
blood vessel | 100% | 7083.73 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 3144.04 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 39.18 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.31 | 1 / 1 |
adipose | 100% | 5094.23 | 1203 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 4534.01 | 802 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 27.14 | 79 / 80 |
heart | 97% | 5829.49 | 834 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 93% | 15.49 | 27 / 29 |
peripheral blood | 29% | 1119.99 | 271 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0035024 | Biological process | negative regulation of Rho protein signal transduction |
GO_0030879 | Biological process | mammary gland development |
GO_0010976 | Biological process | positive regulation of neuron projection development |
GO_0021955 | Biological process | central nervous system neuron axonogenesis |
GO_0097485 | Biological process | neuron projection guidance |
GO_0008064 | Biological process | regulation of actin polymerization or depolymerization |
GO_0030900 | Biological process | forebrain development |
GO_0043116 | Biological process | negative regulation of vascular permeability |
GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
GO_0007413 | Biological process | axonal fasciculation |
GO_0045724 | Biological process | positive regulation of cilium assembly |
GO_0050770 | Biological process | regulation of axonogenesis |
GO_0044319 | Biological process | wound healing, spreading of cells |
GO_0030950 | Biological process | establishment or maintenance of actin cytoskeleton polarity |
GO_0001843 | Biological process | neural tube closure |
GO_0007266 | Biological process | Rho protein signal transduction |
GO_0008360 | Biological process | regulation of cell shape |
GO_0043010 | Biological process | camera-type eye development |
GO_0008361 | Biological process | regulation of cell size |
GO_0016477 | Biological process | cell migration |
GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
GO_0007411 | Biological process | axon guidance |
GO_0005886 | Cellular component | plasma membrane |
GO_0015629 | Cellular component | actin cytoskeleton |
GO_0005829 | Cellular component | cytosol |
GO_0036064 | Cellular component | ciliary basal body |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0005543 | Molecular function | phospholipid binding |
GO_0005096 | Molecular function | GTPase activator activity |
GO_0005525 | Molecular function | GTP binding |
GO_0003924 | Molecular function | GTPase activity |
Gene name | ARHGAP35 |
Protein name | Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A) Rho GTPase-activating protein 35 |
Synonyms | GRLF1 p190ARHOGAP P190A KIAA1722 GRF1 |
Description | FUNCTION: Rho GTPase-activating protein (GAP) . Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity . This binding is inhibited by phosphorylation by PRKCA . Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences . . |
Accessions | ENST00000672722.1 Q9NRY4 A0A2X0SFV3 |