ARHGAP35 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035024Biological processnegative regulation of Rho protein signal transduction
GO_0030879Biological processmammary gland development
GO_0010976Biological processpositive regulation of neuron projection development
GO_0021955Biological processcentral nervous system neuron axonogenesis
GO_0097485Biological processneuron projection guidance
GO_0008064Biological processregulation of actin polymerization or depolymerization
GO_0030900Biological processforebrain development
GO_0043116Biological processnegative regulation of vascular permeability
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0007413Biological processaxonal fasciculation
GO_0045724Biological processpositive regulation of cilium assembly
GO_0050770Biological processregulation of axonogenesis
GO_0044319Biological processwound healing, spreading of cells
GO_0030950Biological processestablishment or maintenance of actin cytoskeleton polarity
GO_0001843Biological processneural tube closure
GO_0007266Biological processRho protein signal transduction
GO_0008360Biological processregulation of cell shape
GO_0043010Biological processcamera-type eye development
GO_0008361Biological processregulation of cell size
GO_0016477Biological processcell migration
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0007411Biological processaxon guidance
GO_0005886Cellular componentplasma membrane
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0036064Cellular componentciliary basal body
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0005543Molecular functionphospholipid binding
GO_0005096Molecular functionGTPase activator activity
GO_0005525Molecular functionGTP binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameARHGAP35
Protein nameRho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A)
Rho GTPase-activating protein 35
SynonymsGRLF1
p190ARHOGAP
P190A
KIAA1722
GRF1
DescriptionFUNCTION: Rho GTPase-activating protein (GAP) . Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity . This binding is inhibited by phosphorylation by PRKCA . Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences . .

AccessionsENST00000672722.1
Q9NRY4
A0A2X0SFV3