ARHGAP18 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0008360Biological processregulation of cell shape
GO_2000145Biological processregulation of cell motility
GO_0030833Biological processregulation of actin filament polymerization
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0001726Cellular componentruffle
GO_0016607Cellular componentnuclear speck
GO_0005829Cellular componentcytosol
GO_0005881Cellular componentcytoplasmic microtubule
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0045296Molecular functioncadherin binding
GO_0005096Molecular functionGTPase activator activity

IV. Literature review

[source]
Gene nameARHGAP18
Protein nameRho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18)
Synonyms
DescriptionFUNCTION: Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state . Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 . Regulates cell shape, spreading, and migration . .

AccessionsQ8N392
ENST00000368149.3 [Q8N392-1]